2009 Fiscal Year Final Research Report
Construction of a system to develop immunotherapy by exploiting the computational algorithm to identify HLA-binding peptides.
| Project/Area Number |
19510209
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied genomics
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| Research Institution | Kochi University |
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Principal Investigator |
UDAKA Keiko Kochi University, 教育研究部医療学系, 教授 (40263066)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 免疫学 / ゲノム / 癌 / トランスレーショナルリサーチ / 医療・福祉 |
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| Research Abstract |
We have developed a system to establish immunotherapies against tumors and viruses by exploiting the computational algorithm to identify HLA-binding peptides. We further developed a method to recruit Th1 cells by including Pertussis whole cell vaccine as an adjuvant in order to induce highly cytotoxic T lymphocytes. After testing on mouse models we conducted phase I/II clinical trials for patients suffering from malignant tumors or chronic hepatitis C virus infection. Tumor control rate obtained was twice the percentage using HLA-binding peptides alone. A long-term tumor control was further observed.
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[Journal Article] WT1 (Wilms' tumor 1) peptide immunotherapy for renal cell carcinoma2007
Author(s)
Iiyama T., Takeda S., Udaka K., Takeuchi T., Adachi Y.C., Shuin T., Ohtsuki Y., Oka Y., Tsuboi A., Nakatsuka S., Eliseeva O.A., Oji Y., Nakajima H., Kawakami M., Nishida S., Shirakata T., Sugiyama H
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Journal Title
Microbiol Imunol 51(5)
Pages: 519-530
Peer Reviewed
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