2010 Fiscal Year Final Research Report
Effects of exposure to endocrine disruptor during gestation and lactation period on motherhood in female mice.
| Project/Area Number |
19530659
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental psychology
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| Research Institution | Kagoshima University |
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Principal Investigator |
TOMIHARA Kazuya Kagoshima University, 法文学部, 教授 (00272146)
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Sonoko 筑波大学, 人間総合科学研究科, 教授 (50396610)
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| Project Period (FY) |
2007 – 2010
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| Keywords | エストロゲン / 行動神経内分泌 / 母性行動 / ジエチルスチルベストロール / 情動性 / 認知・学習 / 育児放棄 / マウス |
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| Research Abstract |
The aim of this study was to demonstrate effects of endocrine disruption during gestation and lactation period on motherhood. We orally administered diethylstilbestrol (DES), a synthetic nonsteroidal estrogen, to pregnant female mice of C57BL/6j strain from their gestation day 11 to 17, or to postpartum day 6, and then investigated their maternal, emotional, social, and learning behavior. As the results, the endocrine disruption during gestation period influenced many behavioral aspects of mother, such as decreased maternal behavior and prevention of learning, although all of the effects may not give the mother a disadvantage.
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