2009 Fiscal Year Final Research Report
Analysis of properties of the marble burying behavior in mice : development of a rapid screening system for psychoactive drugs
| Project/Area Number |
19530670
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental psychology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
YAMADA Kazuyuki The Institute of Physical and Chemical Research, 動物実験支援ユニット, 専門職研究員 (50212288)
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| Co-Investigator(Renkei-kenkyūsha) |
HOMMA Chihiro 独立行政法人理化学研究所, 動物実験支援ユニット, テクニカルスタッフ
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| Project Period (FY) |
2007 – 2009
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| Keywords | 防御的覆い隠し行動 / ガラスビーズ覆い隠し行動 / 床材 / 情動 / 抗鬱薬 / 抗不安薬 / マウス |
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| Research Abstract |
The aim of this study was to develop a rapid screening system for psychoactive drugs such as anxiolitics and/or untidepressants using the marble burying behavior (MB) in mice. First, the significant correlation was showed between physical properties of bedding materials and MB (FY 2007), and detailed replications were done and reported the results in an international journal (FY 2008-9). Then, it was shown that there were suitable bedding materials in the evaluation of some psychoactive drugs by MB (FY 2008). Furthermore, some results suggested that using an appropriate mouse strain should be more effective to evaluate certain drugs (FY 2009).
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