2009 Fiscal Year Final Research Report
Microscopic and spectroscopic study on interactions of membrane-lytic peptides with biomembranes.
| Project/Area Number |
19540425
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biophysics/Chemical physics
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| Research Institution | Tohoku University |
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Principal Investigator |
OHBA Tetsuhiko Tohoku University, 大学院・理学研究科, 助教 (10250664)
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| Co-Investigator(Kenkyū-buntansha) |
OHKI Kazuo 東北大学, 大学院・理学研究科, 教授 (80115394)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 膜破壊性ペプチド / 顕微分光 / 膜流動性イメージング / ミューラ行列顕微鏡 |
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| Research Abstract |
Naturally occurring polypeptides, which length of amino acid sequence is ranged from a ten to several tens, have abilities to corrupt biomembrane structure of bacteria and therefore are expected alternatives for antibiotics. We studied interactions of such membrane-lytic peptides with biomembranes by microscopic and spectroscopic methods and elucidated that the structure formed by melittin and DMPC is not ordinary vesicle structure proposed in the past study.
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