2009 Fiscal Year Final Research Report
Synthesis of Chiral Receptors by Dynamic Combinatorial Approach
| Project/Area Number |
19550111
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Shibaura Institute of Technology |
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Principal Investigator |
NAKAMURA Asao Shibaura Institute of Technology, 工学部, 教授 (50155818)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 動的コンビナトリアル化学 / エナンチオ選択性 / リセプター / ホスト分子 / テンプレート / シクロデキストリン / クラウンエーテル |
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| Research Abstract |
A new method for the synthesis of receptors displaying high selectivity for one of the enantiomers has been developed. The method is based on dynamic combinatorial chemistry using reversible disulfide exchange reaction. By this method two 18-crown-6 moieties could be introduced into the rim of cyclodextrin in the presence of a target α,ω-diamine regioselectively to fit to the target diamine guest molecule. This result shows a possibility for the synthesis of chiral receptors by applying this approach.
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