2009 Fiscal Year Final Research Report
Exploitation of aerobic catalytic oxidation reaction under mild conditions
| Project/Area Number |
19550115
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Okayama University of Science |
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Principal Investigator |
MURAHASHI Shun-Ichi Okayama University of Science, 客員教授(常勤扱) (60029436)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 酸素酸化反応 / C-H結合活性化 / ルテニウム触媒 / Biomimetic反応 / アミンの酸化 / シアノアミンの合成 / アミノ酸合成 / 不活性炭化水素の酸化 |
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| Research Abstract |
Ruthenium-catalyzed oxidative cyanation of tertiary amines with molecular oxygen in the presence of sodium cyanide and acetic acid gives the corresponding α-aminonitriles, which are highly useful intermediates for organic synthesis. The reaction is the first demonstration of direct sp^3C-H bond activation α to nitrogen followed by carbon-carbon bond formation under aerobic oxidation conditions.
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