2009 Fiscal Year Final Research Report
Synthesis of chiral quaternary ammonium polymers and their application to asymmetric reaction
| Project/Area Number |
19550122
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Polymer chemistry
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| Research Institution | Toyohashi University of Technology |
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Principal Investigator |
ITSUNO Shinichi Toyohashi University of Technology, 工学部, 教授 (50158755)
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| Co-Investigator(Kenkyū-buntansha) |
HARAGUCHI Naoki 豊橋技術科学大学, 工学部, 助教 (30378260)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 光学活性高分子 |
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| Research Abstract |
Although a substantial amount of work has been carried out using a side chain functionalized polymers, only a limited number of investigations have been performed to elucidate the use of main-chain functional polymers. The main-chain chiral polymer catalysts having rigid and sterically regular structure may have a better defined microenvironment at the catalytic sites and have allowed a systematic modification of their catalytic properties. We have synthesized two different types of chiral main-chain polymers containing quaternary ammonium salt structure. These chiral polymers were used as catalyst for asymmetric alkylation reaction of N-diphenylmethylidene glycine tert-butyl ester to give phenylalanine derivative in high level of enantioselectivity.
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