2009 Fiscal Year Final Research Report
Development of fluorescent probes based on calixarene-coated water soluble quantum dots
Project/Area Number |
19550157
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Chemistry related to living body
|
Research Institution | Osaka University |
Principal Investigator |
JIN Takashi Osaka University, 免疫学フロンティア研究センター, 特任教授 (80206367)
|
Co-Investigator(Renkei-kenkyūsha) |
KINJO Masataka 北海道大学, 大学院・先端生命科学研究院, 教授 (70177971)
|
Project Period (FY) |
2007 – 2009
|
Keywords | カリックスアレーン / 半導体量子ドット / 蛍光プローブ / 表面被覆 / 水溶化 |
Research Abstract |
A novel method for preparing water-soluble highly fluorescent semiconductor quantum dots was developed using amphiphilic calixarenes as surface coating agents. The fluorescence efficiency of the resulting quantum dots was about 5 times higher than that of the quantum dots prepared by using simple thiol compounds as surface coating agents. The surface of the calixarene-coated quantum dots can be easily modified with biomolecules such as antibodies, showing their utility as fluorescent probes for live cell imaging.
|
Research Products
(22 results)