2009 Fiscal Year Final Research Report
Regioselective substitution of inositol based on its solubilization in DMSO and synthesis of inositol-based functional materials
| Project/Area Number |
19550166
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Ehime University |
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Principal Investigator |
WATANABE Yutaka Ehime University, 大学院・理工学研究科, 教授 (40114722)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 合成化学 / イノシトール / 選択的反応 / DMSO / 糖化学 |
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| Research Abstract |
A new method for the selective introduction of a substituent to inositol was developed by its solubilization in special solvents. The method realized one-step synthesis of a desired one or two substituted inositol derivative, which is required five steps at least to prepare in usual manner. We designed and made some derivatives to explore a biologically active and surface-active materials. The problematic solvents used here directed us to develop a new method for the synthesis of 3-ketoamide, and a tin-mediated substitution reaction.
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