2009 Fiscal Year Final Research Report
Development of Nitric Oxide Responsible Peptide-Metal Complex Conjugate and Its Application
| Project/Area Number |
19550170
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Konan University |
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Principal Investigator |
FUJII Satoshi Konan University, フロンティアサイエンス学部, 准教授 (80271518)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 生物無機化学 |
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| Research Abstract |
We succeeded in developing an iron complex that can make a three helix bundle structure with helical peptides attached to the dithiocarbamate ligand. This iron complex has high affinity toward nitric oxide. Thermal stability of the bundle structure can be controlled by the peptide length and the bundle is stable at around 37℃ with 22 amino acid residues. Moreover, the bundle is collapsed with the nitric oxide binding to the iron ion. These results suggest that this complex can be used as a carrier for drug delivery system that responds to inflammation and nitric oxide.
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