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2008 Fiscal Year Final Research Report

Crystal structures of penicillin binding proteins from Haemophilus influenzae

Research Project

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Project/Area Number 19570109
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Structural biochemistry
Research InstitutionYokohama City University

Principal Investigator

PARK Sam-yong  Yokohama City University, 生命ナノシステム科学研究科, 准教授 (20291932)

Co-Investigator(Kenkyū-buntansha) JEREMY Tame  横浜市立大学, 生命ナノシステム科学研究科, 教授 (00336588)
UNZAI Satoru  横浜市立大学, 生命ナノシステム科学研究科, 助教 (60336592)
Project Period (FY) 2007 – 2008
Keywords構造生物学
Research Abstract

細菌の細胞壁は、浸透圧や外界からの物理的損傷から自身を守り、成長や分裂時には盛んに生合成される組織の1つである。ペニシリンを代表とするβ-ラクタム系抗生物質は、もっとも古くから使用されてきた1つであり、主にグラム陰性菌に対して非常に有効で、現在も、最も多く使用されている抗菌剤である。本研究の目的は、インフルエンザ菌由来のPBPsの立体構造を解明し、新たなインフルエンザ菌の新抗生剤開発を行う予定である。

  • Research Products

    (15 results)

All 2008 2007 Other

All Journal Article (6 results) Presentation (8 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] A Common Mechanism for the ATP-DnaA-dependent Formation of Open Complexes at the Replication Origin2008

    • Author(s)
      Ozaki S, Kawakami H, Nakamura K, Fujikawa N, Kagawa W, Park SY, Yokoyama S, Kurumizaka H, Katayama T
    • Journal Title

      J Biol Chem. 283(13)

      Pages: 8351-62

  • [Journal Article] Crystal structures of the clock protein EA4 from the silkworm Bombyx mori2008

    • Author(s)
      Hiraki T, Shibayama N, Akashi S, Park SY
    • Journal Title

      J Mol Biol. 377(3)

      Pages: 630-5

  • [Journal Article] The structural basis for an essential subunit interaction in influenza virus RNA polymerase2008

    • Author(s)
      Obayashi E, Yoshida H, Kawai F, Shibayama N, Kawaguchi A, Nagata K, Tame JR, Park SY
    • Journal Title

      Nature. 454(7208)

      Pages: 1127-31

  • [Journal Article] Structure and mechanism of HpcG, a hydratase in the homoprotocatechuate degradation pathway of Escherichia coli2007

    • Author(s)
      Izumi A, Rea D, Adachi T, Unzai S, Park SY, Roper DI, Tame JR
    • Journal Title

      J Mol Biol. 370(5)

      Pages: 899-911

  • [Journal Article] Dynamic allostery in the ring protein TRAP2007

    • Author(s)
      Heddle JG, Okajima T, Scott DJ, Akashi S, Park SY, Tame JR
    • Journal Title

      J Mol Biol. 371(1)

      Pages: 154-67

  • [Journal Article] Protonation States of Buried Histidine Residues in Human Deoxyhemoglobin Revealed by Neutron Crystallography2007

    • Author(s)
      Chatake T, Shibayama N, Park SY, Kurihara K, Tamada T, Tanaka I, Niimura N, Kuroki R, Morimoto Y
    • Journal Title

      J Am Chem Soc. 129(48)

      Pages: 14840-1

  • [Presentation] Studies of protein-protein and protein-RNA complexes by mass spectrometry, IUCr2008

    • Author(s)
      Satoko Akashi, Masahiro Watanabe, Jonathan GHeddle, Satoru Unzai, Park SY, Jeremy R.H.Tame
    • Organizer
      第21回国際結晶学連合会議
    • Place of Presentation
      大阪
    • Year and Date
      20080823-31
  • [Presentation] Protonation states of buried histidine residues in human deoxyhemoglobin revealed by neutron crystallography2008

    • Author(s)
      Park SY, Toshiyuki Chatake, Naoya Shibayama, Yukiko Morimoto
    • Organizer
      XVth International Conference on Oxygen Binding and Sensing Proteins
    • Place of Presentation
      Aarhus, Denmark
    • Year and Date
      20080817-21
  • [Presentation] Crystal structure of the clock protein EA4 from the silkworm bombyx mori2008

    • Author(s)
      Park SY, H. Hiraki, N. Shibayama, S. Akashi
    • Organizer
      2^<nd> International conference on protein science
    • Place of Presentation
      Cairns Ausrralia
    • Year and Date
      20080622-26
  • [Presentation] Crystal structures of the clock protein EA4 from the silkworm bombyx mori2008

    • Author(s)
      Park SY, T.Hiraki, N.Shibayama, S.Akashi
    • Organizer
      The Joint 4th AOHUPO(Asian Oceania Human Proeome Organisation and 2nd PRICPS(Pacific Rim International Conference on Protein Science
    • Place of Presentation
      Cairns, Australia
    • Year and Date
      20080622-26
  • [Presentation] Haemoglobin as a drug target2008

    • Author(s)
      Takeshi Yokoyama, Satoru Unzai, Park SY, Jeremy Tame
    • Organizer
      The40th crystallographic meeting at Erice
    • Place of Presentation
      Italy
    • Year and Date
      20080529-0608
  • [Presentation] Dynamic allostery in the ring protein TRAP. Biophysics of ligand binding to drug targets. Workshop2007

    • Author(s)
      Heddle JG, Akashi S, Park SY, Tame JR
    • Organizer
      llkirch, Strasbourg
    • Place of Presentation
      France
    • Year and Date
      20070514-16
  • [Presentation] Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli2007

    • Author(s)
      Park SY, JRH Tame
    • Organizer
      Biophysics of ligand binding to drug targets. Workshop, llkirch, Strasbourg
    • Place of Presentation
      France
    • Year and Date
      20070514-16
  • [Presentation] Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli2007

    • Author(s)
      Park SY, JRH Tame
    • Organizer
      24^<th> European Crystallographic Meeting
    • Place of Presentation
      Marrakech, Morocco
    • Year and Date
      20070000
  • [Patent(Industrial Property Rights)] 新規抗生剤の開発

    • Inventor(s)
      朴三用
    • Industrial Property Rights Holder
      横浜市立大学
    • Industrial Property Number
      特願2008-213424

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Published: 2010-06-10   Modified: 2016-04-21  

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