2009 Fiscal Year Final Research Report
Analysis of regulatory mechanism of extracellular signal by endocytosis
| Project/Area Number |
19570120
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
TOSHIMA Jiro Tokyo University of Science, 基礎工学部・生物工学科, 講師 (00333831)
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| Project Period (FY) |
2007 – 2009
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| Research Abstract |
Endocytic internalization of receptor plays a critical role in down-regulation of receptor-mediated signaling, such as cell growth and differentiation. Here we identify recruitment of receptors to pre-existing clathrin-coated pits as a key step regulated by receptor phosphorylation and subsequent ubiquitination upon ligand binding.
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