2008 Fiscal Year Final Research Report
The Alternative regulation of chromatin structure
Project/Area Number |
19570162
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Molecular biology
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Research Institution | The University of Tokyo |
Principal Investigator |
TAKEYAMA Ken-ichi The University of Tokyo, 分子細胞生物学研究所, 講師 (30323570)
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Co-Investigator(Kenkyū-buntansha) |
KITAGAWA Hirochika 東京大学, 分子細胞生物学研究所, 特任講師 (20345234)
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Project Period (FY) |
2007 – 2008
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Keywords | 染色体構築 / 機能 / 分配 / クロマチン環境制御 |
Research Abstract |
本研究は、組織や時期特異的な転写制御機構を解明するため、新たなクロマチン環境制御機構に着目し、これまで独自に構築した分子遺伝学的手法により解析を行った。その結果、新規ヒストンシャペロンの同定やヘテロクロマチン領域におけるヒストンアセチル化転移酵素の新たな機能を見出した。さらに、細胞周期に応じて調節されるヒストン遺伝子発現の分子機構や、インスレーターの新たな機能制御機構を明らかにした。以上の成果は、各々選択的なクロマチン構造調節機構を示しており、組織や時期特異的な転写制御機構解明の一端となった。
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Research Products
(54 results)
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[Journal Article] DNA demethylation forhormone-induced transcriptionalderepression2009
Author(s)
Kim, M. S., Kondo, T., Takada, I., Youn, M., Yamamoto, Y., Takahashi, S.,Matsumoto, T., Fujiyama, S., Shirode,Y., Yamaoka, I., Kitagawa, H.,Takeyama, K., Shibuya, H., Ohtake, F. and Kato, S
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Journal Title
Peer Reviewed
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[Journal Article] GlcNAcylation of a histonemethyltransferase in retinoicacid-induced granulopoiesis2009
Author(s)
Fujiki, R., Chikanishi, T., Hashiba, W., Ito, H., Takada, I., Roeder, R. G., Kitagawa, H. and Kato, S
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Journal Title
Nature 459
Pages: 455-459
Peer Reviewed
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[Journal Article] AberrantE2F activation by polyglutamineexpansion of androgen receptor inSBMA neurotoxicity2009
Author(s)
Suzuki, E., Zhao, Y., Ito, S., Sawatsubashi, S., Murata, T., Furutani, T., Shirode, Y., Yamagata, K., Tanabe, M., Kimura, S., Ueda, T., Fujiyama, S., Lim, J., Matsukawa, H., Kouzmenko, A. P., Aigaki, T., Tabata, T., Takeyama, K. and Kato, S
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Journal Title
Proc Natl Acad Sci USA 106
Pages: 3818-3822
Peer Reviewed
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[Journal Article] Co-repressiveaction of CBP on androgen receptortransactivation in pericentricheterochromatin in a Drosophilaexperimental model system2008
Author(s)
Zhao, Y., Takeyama, K., Sawatsubashi, S., Ito, S., Suzuki, E., Yamagata, K.,Tanabe, M., Kimura, S., Fujiyama, S., Ueda, T., Murata, T., Matsukawa, H., Shirode, Y., Kouzmenko, A. P., Li, F., Tabata, T. and Kato, S
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Journal Title
Mol Cell Biol 29
Pages: 1017-1034
Peer Reviewed
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[Journal Article] Activation of facultativelysilenced Drosophila loci associateswith increased acetylation of histoneH2AvD.2008
Author(s)
Tanabe, M., Kouzmenko, AP., Ito, S.,Sawatsubashi, S., Suzuki, E.,Fujiyama, S., Yamagata, K., Zhao, Y., Kimura, S., Ueda, T., Murata, T., Matsukawa, H., Takeyama, K. and Kato, S.
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Journal Title
Genes Cells 13
Pages: 1279-1288
Peer Reviewed
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[Journal Article] RNA-binding protein hoipaccelerates polyQ inducedneurodegeneration in Drosophila2008
Author(s)
Murata, T., Suzuki, E., Ito, S., Sawatsubashi, S., Zhao, Y., Yamagata,K., Tanabe, M., Fujiyama, S., Kimura,S., Ueda, T., Matsukawa, H., Kouzmenko, A., Furutani, T., Kuranaga,E., Miura, M., Takeyama, K. and Kato, S
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Journal Title
Biosci Biotechnol Biochem 72
Pages: 2255-2261
Peer Reviewed
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[Journal Article] Drosophila argininemethyltransferase 1 (DART1) is anecdysone receptor co-repressor2008
Author(s)
Kimura, S., Sawatsubashi, S., Ito, S., Kouzmenko, A., Suzuki, E., Zhao, Y.,Yamagata, K., Tanabe, M., Ueda, T., Fujiyama, S., Murata, T., Matsukawa, H., Takeyama, K., Yaegashi, N. and Kato, S
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Journal Title
Biochem Biophys Res Commun 371
Pages: 889-893
Peer Reviewed
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[Journal Article] Switching of chromatin-remodelling complexes for oestrogen receptor-alpha2008
Author(s)
Okada, M., Takezawa, S., Mezaki, Y., Yamaoka, I., Takada, I., Kitagawa, H. and Kato, S.
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Journal Title
EMBO Rep 9
Pages: 563-568
Peer Reviewed
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[Journal Article] A2E, a pigment of thelipofuscin of retinal pigmentepithelial cells, is an endogenousligand for retinoic acid receptor2008
Author(s)
Iriyama, A., Fujiki, R., Inoue, Y.,Takahashi, H., Tamaki, Y., Takezawa, S., Takeyama, K., Jang, W. D., Kato, S. and Yanagi Y
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Journal Title
JBiol Chem 283
Pages: 11947-11953
Peer Reviewed
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[Journal Article] A TFTC/STAGA module mediates histoneH2A and H2B deubiquitination,coactivates nuclear receptors, andcounteracts heterochromatinsilencing2008
Author(s)
Zhao, Y., Lang, G., Ito, S., Bonnet, J., Metzger, E., Sawatsubashi, S., Suzuki, E., Le Guezennec, X., Stunnenberg, H. G., Krasnov, A., Georgieva, S. G., Schule, R., Takeyama, K., Kato, S., Tora, L. and Devys, D
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Journal Title
Mol Cell 29
Pages: 92-101
Peer Reviewed
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[Journal Article] Dihydrotestosteroneinhibits murine hair growth via theandrogen receptor2008
Author(s)
Naito, A., Sato, T., Matsumoto, T., Takeyama, K., Yoshino, T., Kato, S. and Ohdera, M
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Journal Title
Br J Dermatol 159
Pages: 300-305
Peer Reviewed
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[Journal Article] Vitamin K induces osteoblastdifferentiation through pregnane Xreceptor-mediated transcriptionalcontrol of the Msx2 gene2007
Author(s)
Igarashi, M., Yogiashi, Y., Mihara, M., Takada, I., Kitagawa, H. and Kato,S
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Journal Title
Mol Cell Biol 27
Pages: 7947-7954
Peer Reviewed
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[Journal Article] A histone lysine methyltransferaseactivated by non-canonical Wntsignalling suppresses PPAR-gammatransactivation2007
Author(s)
Takada, I., Mihara, M., Suzawa, M., Ohtake, F., Kobayashi, S., Igarashi, M., Youn, M. Y., Takeyama, K., Nakamura, T., Mezaki, Y., Takezawa, S., Yogiashi, Y., Kitagawa, H., Yamada, G., Takada, S., Minami, Y., Shibuya, H., Matsumoto, K. and Kato, S
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Journal Title
Nat Cell Biol 9
Pages: 1273-1285
Peer Reviewed
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[Journal Article] High-throughput system for analyzingligand-induced cofactor recruitmentby vitamin D receptor2007
Author(s)
Arai, M. A., Takeyama, K., Ito, S., Kato, S., Chen, T. C. and Kittaka, A
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Journal Title
Bioconjug Chem 18
Pages: 614-620
Peer Reviewed
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[Journal Article] Androgen receptorfunction in folliculogenesis and itsclinical implication in prematureovarian failure2007
Author(s)
Kimura, S., Matsumoto, T., Matsuyama, R., Shiina, H., Sato, T., Takeyama, K. and Kato, S
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Journal Title
Trends EndocrinolMetab 18
Pages: 183-189
Peer Reviewed
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[Journal Article] DEAD-box RNA helicase subunits ofthe Drosha complex are required forprocessing of rRNA and a subset ofmicroRNAs2007
Author(s)
Fukuda, T., Yamagata, K., Fujiyama, S., Matsumoto, T., Koshida, I., Yoshimura, K., Mihara, M., Naitou, M., Endoh, H., Nakamura, T., Akimoto, C., Yamamoto, Y., Katagiri, T., Foulds, C., Takezawa, S., Kitagawa, H., Takeyama, K., O'Malley, B. W. and Kato, S
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Journal Title
Nat Cell Biol 9
Pages: 604-611
Peer Reviewed
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[Journal Article] Id2gene-targeted crosstalk between Wntand retinoid signaling regulatesproliferation in human keratinocytes2007
Author(s)
Memezawa, A., Takada, I., Takeyama,K., Igarashi, M., Ito, S., Aiba, S., Kato, S. and Kouzmenko, A.P
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Journal Title
Oncogene 26
Pages: 5038-5045
Peer Reviewed
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[Journal Article] A cell cycle-dependent co-repressor mediates photoreceptor cell specific nuclear receptor function2007
Author(s)
Takezawa, S., Yokoyama, A., Okada, M.,Fujiki, R., Iriyama, A., Yanagi, Y., Ito, H., Takada, I., Kishimoto, M., Miyajima, A., Takeyama, K., Umesono, K., Kitagawa, H. and Kato, S
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Journal Title
Peer Reviewed
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[Journal Article] 1Alpha,25(OH)2D3-inducedtransrepression by vitamin D receptorthrough E-box-type elements in thehuman parathyroid hormone genepromoter2007
Author(s)
Kim, M.S., Fujiki, R., Murayama, A., Kitagawa, H., Yamaoka, K., Yamamoto, Y., Mihara, M., Takeyama, K. and Kato, S
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Journal Title
Mol Endocrinol 21
Pages: 334-342
Peer Reviewed
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[Presentation] Switching ofchromatin-remodeling complexes forestrogen receptorα.2008
Author(s)
Okada, M., Takezawa, S., Mezaki, Y., Yamaoka, I., Takada, I., Kitagawa, H., Kato, S.
Organizer
2008 KeystoneSymposia Conference (Molecular Basisfor Chomatin Modifications andEpigenetic Phenomena).
Place of Presentation
Snowmass, USA
Year and Date
20080407-13
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[Presentation] Transrepressive function of TLXrequires the histone demethylase, LSD1.2008
Author(s)
Yokoyama, A., Takezawa, S., Schule, R., Kitagawa, H., Kato, S
Organizer
2008 Keystone Symposia Conference (Molecular Basis for Chomatin Modifications and Epigenetic Phenomena).
Place of Presentation
Snowmass, USA
Year and Date
20080407-13
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[Presentation] Analysis of a novelco-repressor, Z4 with Drosophilamolecular genetics and proteomics.2008
Author(s)
Murata, T., Sawatsubashi, S., Ito, S., Zhao, Y., Yamagata, K., Suzuki, E., Tanabe, M., Fujiyama, S., Kimura, S., Ueda, T., Matsukawa, H., Takeyama, K., Kato, S.
Organizer
2008 Keystone Symposia Conference(Molecular Basis for ChomatinModifications and EpigeneticPhenomena).
Place of Presentation
Snowmass, USA
Year and Date
20080407-13
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[Presentation] Drosophila argininemethyltransferase 1 (DART1)modulates ecdysonereceptor-mediated transcription inDrosophila metamorphosis.2008
Author(s)
Kimura, S., Ito, S., Sawatsubashi, S., Kouzmenko, A., Suzuki, E., ZhaoY., Yamagata, K., Tanabe, M., Ueda, T., Fujiyama, S., Murata, T., Matsukawa, H., Takeyama, K., Kato, S.
Organizer
2008Keystone Symposia Conference(Molecular Basis for ChomatinModifications and EpigeneticPhenomena).
Place of Presentation
Snowmass, USA
Year and Date
20080407-13
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[Presentation] Novelcorepressor, SNASH inducesneurogenesis through thetranscriptional repressing for notchsignaling.2008
Author(s)
Takeyama, K., Ito, S., Sawatsubashi, S., Kouzmenko, A., Suzuki, E., Zhao, Y., Yamagata, K., Tanabe, M., Kimura, S., Ueda, T., Murata, T., Matsukawa, H., Fujiyama, S., Hirabayashi, Y., Gotoh, Y., Kato, S.
Organizer
2008 Keystone SymposiaConference (Nuclear Receptors : Orphan Brothers).
Place of Presentation
Whistler, Canada
Year and Date
20080329-0405
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[Presentation] Aberrant expression of a novelandrogen corepressor intesticular tumors2008
Author(s)
Ueda, T., Ito, S., Sawatusubashi, S., Kouzmenko, A., Suzuki, E., Yamagata,K., Zhao, Y., Tanabe, M., Kimura, S.,Murata, T., Matsukawa, H., Fujiyama,S., Miki, T., Takeyama, K., Kato, S.
Organizer
2008 KeystoneSymposia Conference (NuclearReceptors : Orphan Brothers).
Place of Presentation
Whistler, Canada
Year and Date
20080329-0405
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[Presentation] Identificatioin of novel function toregulate chromatin formation throughDcr-2/Ago2 pathway.2008
Author(s)
Suzuki, E., Sawatsubashi, S., Ito, S., Zyao, Y., Yamagata, K., Tanabe, M., Kimura, S., Ueda, T., Murata, T., Fujiyama, S., Matsukawa, H., Kouzmenko, A., Takeyama, K., Tomari,Y., Siomi, H., Kato, S.
Organizer
2008 KeystoneSymposia Conference (RNAi, MicroRNA, and Non-Codin RNA).
Place of Presentation
Whistler, Canada
Year and Date
20080325-0401
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[Presentation] Identification of MDC1 thatenhances androgen receptortransactivation.2007
Author(s)
Zhao, Y., Takeyama, K., Sawatsubashi, S., Ito, S., Suzuki, E., Yamagata, K., Shirode, Y., Tanabe, M., Kimura, S., Fujiyama, S., Ueda, T., Murata, T., Matsukawa, H., Kouzmenko, A., Kato, S
Organizer
第30回日本分子生物学会、第80回日本生化学会合同大会.
Place of Presentation
横浜
Year and Date
20071211-15
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