2009 Fiscal Year Final Research Report
Research on the role of microtubule plus-end tracking proteins in the reorganization of microtubule array upon cell membrane disruption
| Project/Area Number |
19570175
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | St.Marianna University School of Medicine |
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Principal Investigator |
TOGO Tatsuru St.Marianna University School of Medicine, 医学部, 講師 (40334247)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 膜修復 / 微小管 / プラス端集積因子 / adenomatous polyposis coli / EB1 / カルシウム / GSK-3β / チロシンキナーゼ |
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| Research Abstract |
Microtubule (MT) plus end tracking proteins (+TIPs) are involved in the regulation of MT dynamics. It was reported previously that an increase in intracellular Ca^<2+> concentration ([Ca^<2+>]_i) induced by cell membrane disruption stimulates rearrangement of MTs, suggesting that some +TIPs are regulated by Ca^<2+>.In the present study. the behaviors of +TIPs following an increase in [Ca^<2+>]_i was observed. Disruption of plasma membrane and increase in [Ca^<2+>]_i stimulates redistribution of denomatous polyposis coli (APC) AND EB1. Present study also indicated that Ca^<2+> stimulates redistribution of APC throuht a tyrosine kinase- and GSK-3β-dependent pathway.
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