2009 Fiscal Year Final Research Report

Regulation mechanism of intracellular coenzyme A by pantothenate kinase in Archaea

Research Project

Project/Area Number	19580079
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Applied microbiology
Research Institution	Ibaraki University
Principal Investigator	CHOHNAN Shigeru Ibaraki University, 農学部, 准教授 (70312775)
Project Period (FY)	2007 – 2009
Keywords	パントテン酸キナーゼ / 古細菌 / コエンザイムA
Research Abstract	A gene encoding a pantothenate kinase (CoaA) which is a key enzyme in coenzyme A biosynthetic pathway has been identified in a thermoacidophilic archaeon. The archaeal CoaA belongs to a prokaryotic type I CoaA and is not governed by feedback inhibition by CoA and its thioesters, although prokaryotic type I CoaAs are generally inhibited by the CoA species. Therefore, CoA biosynthetic pathways in the archaea belonging to the order Thermoplasmatales which has the type I CoaA are not regulated at CoaA step.

(3 results)