Bioorganic Research on Biologically Active Natural Products towards Development of Agrochemical and Medicinal Lead Compounds

2009 Fiscal Year Final Research Report

• Project/Area Number: 19580120
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Bioproduction chemistry/Bioorganic chemistry
• Research Institution: Tohoku University
• Principal Investigator: KIYOTA Hiromasa Tohoku University, 大学院・農学研究科, 准教授 (30234397)
• Project Period (FY): 2007 – 2009
• Keywords: 抗生物質 / 植物毒素 / 海洋天然物 / ジャスモン酸 / タキサンジテルペノイド / 単離構造決定 / 全合成 / 構造活性相関

Research Abstract

Bioorganic research on biologically active natural products have been achieved. Total synthesis : analogs of polynactin antibiotics, phytotoxin T-beta-L and pyricuols, marine antifeedant pteroenone, plant hormone jasmonic acids, and gizzerosine. Patial synthesis : antibiotics pamamycis, spirofungins and enacyloxins, and anti-angiogenetic cortistatins. Isolation and structure elucidation : enacyloxins, taxanes, limonoids and echinopines.

Research Products

• [Journal Article] Synthesis and Plant Growth Inhibitory Activity of Both Enantiomers of Pyricuol (2009)
  • Author(s): K. Tanaka, Y. Nakamura, A. Sasaki, R. Ueda, Y. Suzuki, S. Kuwahara, H. Kiyota
  • Journal Title: a Phytotoxin Isolated from Rice Blast Disease Fungus Magnaporthe grisea、Tetrahedron 65巻 Pages: 6115-6122
  • Peer Reviewed
• [Journal Article] (2008)
  • Author(s): Y. Sato, H. Kamiyama, T. Usui, T. Saito, H. Osada, S. Kuwahara, H. Kiyota
  • Journal Title: Biosci.Biotechnol.Biochem. 72巻 Pages: 2292-2297
  • Peer Reviewed
• [Journal Article] (2008)
  • Author(s): A. Miura, S.-y. Takigawa, Y. Furuya, Y. Yokoo, S. Kuwahara, H. Kiyota
  • Journal Title: Eur.J.Org.Chem. Pages: 4955-4962
  • Peer Reviewed
• [Journal Article] (2008)
  • Author(s): M. Dong, B. Cong, S.-H. Yu, F. Sauriol, C.-H. Huo, Q.-W. Shi, Y.-C. Gu, L. O. Zamir, H. Kiyota
  • Journal Title: Org.Lett. 10巻 Pages: 701-704
  • Peer Reviewed
• [Journal Article] (2007)
  • Author(s): H. Kiyota, T. Takai, Y. Shimasaki, M. Saitoh, O. Nakayama, T. Takada, S. Kuwahara
  • Journal Title: Synthesis Pages: 2471-2480
  • Peer Reviewed
• [Presentation] サリチルアルデヒド型イネいもち病菌毒素類の全合成研究 (2009)
  • Author(s): 佐々木郁香, 田中功二, 中村葉子, 上田留美, 貫名学, 桑原重文, 鈴木雄二, 清田洋正
  • Organizer: 香料・テルペンおよび精油化学に関する討論会
  • Place of Presentation: 奈良
  • Year and Date: 2009-11-07
• [Presentation] 抗腫瘍活性物質 maoecrystal Vの合成研究 (2009)
  • Author(s): 浅尾洋樹, 島崎泰治, 佐々木郁香, 桑原重文, 清田洋正
  • Organizer: 日本農芸化学会2009年度大会
  • Place of Presentation: 福岡
  • Year and Date: 2009-03-29
• [Presentation] 抗生物質 enacyloxin 類のC9'-C23' 部分の合成研究 (2009)
  • Author(s): 五十嵐渉, 星川浩輝, 古川博之, 八尾坂学, 山田てい子, 桑原重文, 清田洋正
  • Organizer: 日本農芸化学会2010年度大会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-28
• [Presentation] イネいもち病菌毒素 pyricuol 及び関連化合物の合成研究 (2008)
  • Author(s): 田中功二, 佐々木郁香, 中村葉子, 桑原重文, 清田洋正
  • Organizer: 有機合成シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-11-08
• [Presentation] 血管新生阻害活性物質 cortistatin 類アナログの合成と生物活性 (2007)
  • Author(s): 佐藤勇気, 神山洋, 長田裕之, 桑原重文, 清田洋正
  • Organizer: 日本農芸化学会東北支部大会
  • Place of Presentation: 仙台
  • Year and Date: 2007-11-10
• [Book] Natural Products : Chemistry, Biochemistry and Pharmacology (2008)
  • Author(s): X.-H. Su, M. Dong, Q.-W. Shi, Y.-C. Gu, H. Kiyota
  • Total Pages: 270-292
  • Publisher: Narosa 社
• [Book] Natural Products : Chemistry, Biochemistry and Pharmacology (2008)
  • Author(s): M. Dong, M.-L. Zhang, Q.-W. Shi, Y.-C. Gu, H. Kiyota
  • Total Pages: 247-269
  • Publisher: Narosa 社
• [Book] Chemistry of Natural Products : Recent Trends and Developments (2007)
  • Author(s): Y.-F. Wang, Q.-W. Shi, H. Kiyota
  • Total Pages: 43-59
  • Publisher: Research Signpost 社