2009 Fiscal Year Final Research Report
Elucidation of fish T lymphocyte subgroup based on the CD4 family marker
| Project/Area Number |
19580220
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General fisheries
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| Research Institution | Fujita Health University |
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Principal Investigator |
J・M Dijkstra Fujita Health University, 総合医科学研究所, 助教 (10387681)
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| Co-Investigator(Renkei-kenkyūsha) |
HAYASHI Nobuhiro 東京工業大学, 大学院・生命理工学研究科・分子生命科学専攻, 准教授 (80267955)
NAKANISHI Teruyuki 日本大学, 生物資源科学部, 教授 (00322496)
HASHIMOTO Keiichiro 藤田保健衛生大学, 総合医科学研究所, 教授 (70192268)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 魚病 / 免疫学的予防 / CD4 / Tリンパ球 / 細胞表面マーカー |
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| Research Abstract |
The main project target was to elucidate the CD4 family of molecules in teleost fish, with clonal ginbuna crucian carp as major fish model. This family of molecules is known to form major markers for leukocyte subpopulations, predominantly of T lymphocytes. We found a homologue of mammalian G6F, a marker of platelets, which we designated G6F-like. We could determine that G6F and G6F-like are related to the CD4 family. A monoclonal antibody against G6F-like was established and we found the molecule expressed in ginbuna thrombocytes and erythrocytes.
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[Journal Article]2007
Author(s)
Suetake H, Araki K, Akatsu K, Somamoto T, Dijkstra JM, Yoshiura Y, Kikuchi K, Suzuki Y.
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Journal Title
Fish Shellfish Immunol. 23
Pages: 1107-1118
Peer Reviewed
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[Journal Article] A molecule in teleost fish, related with human MHC-encoded G6F, has a cytoplasmic tail with ITAM and marks the surface of thrombocytes and in some fishes also of erythrocytes.
Author(s)
Ohashi K, Takizawa F, Tokumaru N, Nakayasu C, Toda H, Fischer U, Morimoto T, Hashimoto K, Nakanishi T, Dijkstra JM.
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Journal Title
Immunogenetics (in press)
Peer Reviewed
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