2008 Fiscal Year Final Research Report
Analysis of physiological functions of the retinoid X receptor in prosobranch gastropods
Project/Area Number |
19580226
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General fisheries
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Research Institution | National Institute for Environmental Studies |
Principal Investigator |
HORIGUCHI Toshihiro National Institute for Environmental Studies, 環境リスク研究センター, 主席研究員 (30260186)
|
Co-Investigator(Kenkyū-buntansha) |
SHIRAISHI Hiroaki 独立行政法人国立環境研究所, 環境リスク研究センター, センター長 (10124348)
OTA Yasuhiko 国立大学法人鳥取大学, 農学部, 教授 (60069078)
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Project Period (FY) |
2007 – 2008
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Keywords | 前鰓類 / インポセックス / レチノイドX受容体 / 雄性生殖器 |
Research Abstract |
前鰓類におけるRXRの機能解析を雄性生殖器の分化・成長との関係に着目して実施した。フィールドでの定期採集によりRXR遺伝子発現と雄性生殖器の発達の季節変化を示し、室内実験によりTBT曝露に伴うペニス形成部位の形態変化とRXR遺伝子発現の経時変化を示した。免疫染色によりRXRが前鰓類に広く分布することを示した。筋肉注射試験の結果、9-cis レチノイン酸の効果にも種差は見られないと考えられた。生殖輸管の分化・形成機序を組織学的に解析した。
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Research Products
(19 results)
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[Presentation] Endocrine disruption caused by organotins in gastropods: from a molecular mechanism to population-level effects2008
Author(s)
Horiguchi, T., Cho, H.S., Imai, T., Hamada, F., Ohta, Y., Iguchi, T., Morishita, F., Matsushima, O., Nagao, T., Nishikawa, J., Shiraishi, F., Shimizu, M., Yamazaki, S., Morita, M., Shiraishi, H.
Organizer
Physical and Chemical Impacts on Marine Organisms -Seeking Sustainability and Postgenomics- pp.13-14
Place of Presentation
Nagoya(Japan)
Year and Date
20081100
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[Presentation] Induction mechanism of imposex caused by organotin compounds in gastropods: evidence concludes involvement of the retinoid X receptor2008
Author(s)
Horiguchi, T., Shiraishi, H., Ohta, Y., Shiraishi, F., Cho, H.S., Morita, M.
Organizer
5th World Fisheries Congress, Program and Abstracts, p.442
Place of Presentation
Yokohama (Japan)
Year and Date
20081000
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[Presentation] Imposex and organotin concentrations in Thais orbita and Morula marginalba around Sydney, Australia2008
Author(s)
Horiguchi, T., Colville, A., Hamilton, L., Shiraishi, F., Nakajima, D., Kamata, R., Lim, R., Shiraishi, H.
Organizer
5th SETAC World Congress
Place of Presentation
Sydney (Australia)
Year and Date
20080800
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[Presentation] Localization of RXR in penis and other tissues of several gastropod species (Muricidae, Buccinidae and Nassariidae) from Japan and Portugal2008
Author(s)
Horiguchi, T., Sousa, A., Ohta, Y., Cho, H.S., Miguez, C., Shiraishi, H.
Organizer
SETAC Europe 18th Annual Meeting, p.150
Place of Presentation
Warsaw (Poland)
Year and Date
20080500
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[Presentation] Annual trend of imposex and organotins content in the Rock shell, Thais clavigera from the coast of Korea2008
Author(s)
Cho, H.S., Park, J.C., Choi, M.K., Choi, H.G., Horiguchi, T.
Organizer
環境ホルモン学会第11回研究発表会, 同講演要旨集, p.164
Place of Presentation
東京
Year and Date
20080000
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[Presentation] Involvement of the retinoid X receptor in the development of imposex caused by organotin compounds in female gastropods2007
Author(s)
Horiguchi, T., Shiraishi, H., Nishikawa, T., Ohta, Y., Shiraishi, F., Cho, H., Nishikawa, J., Morita, M.
Organizer
DIOXIN 2007 International Symposium, p135
Place of Presentation
Tokyo
Year and Date
20070900
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[Presentation] Long term trends of imposex in the rock shell, Thais clavigera and organotin pollutions in the coast of Korea2007
Author(s)
Cho, H.S., Lee, J.H., Cho, C.R., Choi, H.G., Choi, M.G., Horiguchi, T.
Organizer
SETAC (Society of Environmental Toxicology and Chemistry) Europe 17th Annual Meeting, p.224
Place of Presentation
Porto (Portugal)
Year and Date
20070500
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[Presentation] Involvement of the retinoid X receptor in the development of imposex caused by organotins in female gastropods2007
Author(s)
Horiguchi, T., Shiraishi, H., Nishikawa, T., Ohta, Y., Shiraishi, F., Cho, H.S., Nishikawa, J., Morita, M.
Organizer
SETAC(Society of Environmental Toxicology and Chemistry) Europe 17th Annual Meeting, p.31
Place of Presentation
Porto (Portugal)
Year and Date
20070500
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