Identification of responsible gene for chicken muscular dystrophy and the onset mechanism

2008 Fiscal Year Final Research Report

• Project/Area Number: 19580338
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: Kobe University
• Principal Investigator: MANNEN Hideyuki Kobe University, 大学院農学研究科, 准教授 (20263395)
• Co-Investigator(Kenkyū-buntansha): MUKAI Fumio (社)全国和牛登録協会, 会長 (50093323)
• Project Period (FY): 2007 – 2008
• Keywords: 遺伝

Research Abstract

本研究はニワトリ筋ジストロフィーの原因遺伝子を同定し、この疾患の発症機構を明らかにすることが目的である。候補領域内に存在する7遺伝子に対して、翻訳領域の塩基配列を疾患個体と正常個体で比較検討した結果、WWP1遺伝子に観察されたG1321A置換はアミノ酸をアルギニンからグルタミンに置換するものであった。これらの結果から、WWP1遺伝子がニワトリ筋ジストロフィーの最有力原因候補遺伝子であることが示唆された。

Research Products

• [Journal Article] The ubiquitin ligase gene (WWP1) is responsible for the chicken muscular dystrophy (2008)
  • Author(s): Matsumoto, H., H. Maruse, Y. Inaba, K. Yoshizawa, S. Sasazaki, A. Fujiwara, M. Nishibori, A. Nakamura, S. Takeda, N. Ichihara, T. Kikuchi, F. Mukai and H. Mannen
  • Journal Title: FEBS letters 582 Pages: 2212-2218
  • Peer Reviewed
• [Journal Article] Pinpointing the candidate region of muscular dystrophy in chickens with an abnormal muscle gene (2007)
  • Author(s): Matsumoto, Y., H. Maruse, K., Yoshizawa, S. Sasazaki, A. Fujiwara, T. Kikuchi, N. Ichihara, F. Mukai and H. Mannen
  • Journal Title: Anim. Sci. J. 78 Pages: 476-483
  • Peer Reviewed
• [Journal Article] Expression pattern of WWP1 in muscular dystrophic and normal chickens
  • Author(s): Matsumoto, H, H. Maruse, S. Sasazaki, A. Fujiwara, S. Takeda, N. Ichihara, T. Kikuchi, F. Mukai, H. Mannen
  • Journal Title: J. Poult. Sci. (印刷中)
  • Peer Reviewed
• [Presentation] The ubiquitin ligase gene (WWP1) is responsible for the chicken muscular dystrophy (2008)
  • Author(s): Matsumoto, H., H. Maruse, Y. Inaba, K. Yoshizawa, S. Sasazaki, A. Fujiwara, M. Nishibori, A. Nakamura, S. Takeda, N. Ichihara, T. Kikuchi, F. Mukai, H. Mannen
  • Organizer: 31th International Conference on Animal Genetics. Amsterdam
  • Place of Presentation: The Netherlands
  • Year and Date: 20080720-24