TRANSLATIONAL RESEARCH ON A MODEL OF GLYCAN CHAIN MODIFICATION OF ACUTE PHASE PROTEIN

2008 Fiscal Year Final Research Report

• Project/Area Number: 19580370
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Clinical veterinary science
• Research Institution: Yamaguchi University
• Principal Investigator: IWATA Hiroyuki Yamaguchi University, 農学部, 教授 (40193750)
• Co-Investigator(Kenkyū-buntansha): MAEDA Ken 山口大学, 農学部, 准教授 (90284273) ; KATO Hirotomo 山口大学, 農学部, 准教授 (00346579)
• Project Period (FY): 2007 – 2008
• Keywords: 急性期蛋白 / α1酸性糖蛋白 / 糖鎖修飾 / 腫瘍 / ウイルス

Research Abstract

難治性ウイルス感染症ならびに腫瘍における急性期糖蛋白変動解明と新規機能発見を目的に, 炎症に伴って上昇する血中糖蛋白(α1 酸性糖蛋白)を, ウシ血清およびネコ腹水から精製分離し, 各種疾患における変動, 糖鎖を解析し, 特にウシ白血病での血中上昇と糖鎖変動, ネココロナウイルス感染症(伝染性腹膜炎)での血中上昇がみられた.また, 実験動物の肝臓から本蛋白遺伝子のmRNA検出が可能となり, 基礎研究への応用が期待される.

Research Products

• [Journal Article] Detection of multiple sapovirus genotypes and genogroups in oyster-associated outbreaks (2009)
  • Author(s): Nakagawa-Okamoto R, Arita-Nishida T, Toda S, Kato H, Iwata H, Akiyama M, Nishio O, Kimura H, Noda M, Takeda N, Oka T
  • Journal Title: Japanese Journal of Infectious Diseas 62 Pages: 63-66
  • Peer Reviewed
• [Journal Article] Gene expression changes induced by type IV allergyinducible chemicals in dendritic cells (2008)
  • Author(s): Tarama R, Kato H, Ishikawa Y, Miyaura H, Takeyoshi M, Iwata H
  • Journal Title: Journal of Veterinary Medical Science 70 Pages: 673-680
  • Peer Reviewed
• [Journal Article] Natural infection of Lutzomyia tortura with Leishmania (Viannia) naiffi in an Amazonian area of Ecuador (2008)
  • Author(s): Kato H, Gomez EA, Yamamoto Y, Calvopina M, Guevara AG, Marco JD, Barroso PA, Iwata H, Hashiguchi Y
  • Journal Title: American Journal of Tropical Medical Hygiene 79 Pages: 438-440
  • Peer Reviewed
• [Journal Article] olecular typing of sand fly species (Diptera, Psychodidae, Phlebotominae) from areas endemic for Leishmaniasis in Ecuadorby PCR-RFLP of 18S ribosomal RNA gene (2008)
  • Author(s): Terayama Y, Kato H, Gomez EA, Uezato H, Calvopina M, Iwata H, Hashiguchi Y
  • Journal Title: Journal of Veterinary Medical Science 70 Pages: 907-913
  • Peer Reviewed
• [Journal Article] Molecular mass screening to incriminate sand fly vectors of Andean-type cutaneous leishmaniasis in Ecuador and Peru (2008)
  • Author(s): Kato H, Caceres AG, Gomez EA, Mimori T, Uezato H, Marco JD, Barroso PA, Iwata H, Hashiguchi Y
  • Journal Title: American Journal of Tropical Medical Hygiene 79 Pages: 719-721
  • Peer Reviewed
• [Journal Article] Genotyping and quantitation of noroviruses in oysters from two distinct sea areas in Japan (2007)
  • Author(s): Nishida T, Nishio O, Kato M, Chuma T, Kato H, Iwata H, Kimura H
  • Journal Title: Microbiology and Immunology 51 Pages: 177-184
  • Peer Reviewed
• [Journal Article] Differentiation of feline coronavirus type I and II infections by virus neutralization test (2007)
  • Author(s): Shiba N, Maeda K, Kato H, Mochizuki M, Iwata H
  • Journal Title: Veterinary Microbiology 61 Pages: 348-352
  • Peer Reviewed
• [Journal Article] Establishment of a mass screening method of sand fly vectors for Leishmania infection by molecular biological methods (2007)
  • Author(s): Kato H, Uezato H, Gomez EA, Terayama Y, Calvopina M, Iwata H, Hashiguchi Y
  • Journal Title: American Journal of Tropical Medical Hygiene 77 Pages: 324-329
  • Peer Reviewed
• [Presentation] FIP発症ネコ血清にのみ存在する感染増強機構 (2008)
  • Author(s): 寺田豊, 芝希望, 前田健, 水野拓也, 甲斐一成, 望月雅美, 加藤大智, 岩田祐之
  • Organizer: 第146回日本獣医学会学術集会
  • Place of Presentation: 宮崎市
  • Year and Date: 2008-09-25
• [Presentation] Lectin isolated from Momordica charantia seed is a B cell Activator (2008)
  • Author(s): 黄莉, 足立匠, 清水佑也, 後藤義孝, 外山潤, 田中秀典, 明石良, 岩田祐之, 芳賀猛
  • Organizer: 第146回日本獣医学会学術集会
  • Place of Presentation: 宮崎市
  • Year and Date: 2008-09-25
• [Presentation] IV型アレルギー誘発性化学物質によって樹状細胞に誘導される遺伝子変動の解析 (2007)
  • Author(s): 多良間理絵, 加藤大智, 石川陽一, 武吉正博, 岩田祐之
  • Organizer: 第146回日本獣医学会学術集会
  • Place of Presentation: つくば市
  • Year and Date: 2007-04-04
• [Presentation] ウイルス中和試験を用いたネココロナウイルス感染の血清疫学的解析 (2007)
  • Author(s): 芝希望, 前田健, 加藤大智, 望月雅美, 岩田祐之
  • Organizer: 第146回日本獣医学会学術集会
  • Place of Presentation: つくば市
  • Year and Date: 2007-04-03