2009 Fiscal Year Final Research Report
A research for the chitinolytic systems of bacteria
| Project/Area Number |
19580386
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Boundary agriculture
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| Research Institution | Osaka University of Pharmaceutical Sciences |
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Principal Investigator |
TSUJIBO Hiroshi Osaka University of Pharmaceutical Sciences, 薬学部, 教授 (90175464)
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| Project Period (FY) |
2007 – 2009
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| Keywords | バイオマス / 海洋細菌 / キチン |
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| Research Abstract |
We have clarified that four chitinases (ChiA, ChiB, ChiC, and ChiD), three β-N-acetylglucosaminidases (GlcNAcases A, B, and C), a transglycosylative enzyme (Hex99), a chitin-binding protein (Cbp1), and two proteases (AprIV and MprIII) are involved in chitin degradation of the marine bacterium, Alteromonas sp. strain O-7. Recently, the glmS gene coding for one of the key enzymes of GlcNAc utilization was cloned, and the function and regulation of the enzyme was clarified. Furthermore, the genome analysis of strain O-7 was performed by Illumina Genome Analyzer. The homology search indicated that there are additional chitinase-, chitin-binding protein-, and N-acetylglucosaminidase-encoding genes in the genome.
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[Journal Article] The dasABC gene cluster, adjacent to dasR, encodes a novel ABC transporter for the uptake of N, N'-diacetylchitobiose in Streptomyces coelicolor A3(2).2007
Author(s)
Akihiro Saito, Tomonori Shinya, Katsushiro Miyamoto, Tomofumi Yokoyama, Hanae Kaku, Eiichi Minami, Naoto Shibuya, Hiroshi Tsujibo, Yoshiho Nagata, Akikazu Ando, Takeshi Fujii, Kiyotaka Miyashita
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Journal Title
Appl. Environ. Microbiol 73
Pages: 3000-3008
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[Journal Article] Structure-activity relationship and biological property of cortistatins, anti-angiogenic spongean steroidal alkaloids.2007
Author(s)
Shunji Aoki, YasuoWatanabe, Daiki Tanabe, Masayoshi Arai, Hideaki Suna, Katsushiro Miyamoto, Hiroshi Tsujibo, Kazutake Tsujikawa, Hiroshi Yamamoto, Motomasa Kobayashi
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Journal Title
Bioorg. Med. Chem 15
Pages: 6758-6762
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