2009 Fiscal Year Final Research Report
The screening of the new functional compounds for the prevention of cardiovascular events.
| Project/Area Number |
19589002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
KAJIYA Katsuko Yamaguchi University, 大学院・医学系研究科, 助教 (00379942)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 心血管イベント / 機能性食品 / 高脂血症(脂質異常症) / コレステロール / リポソーム / 膜ドメイン / シグナル伝達 / 血管攣縮 |
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| Research Abstract |
Abnormal vascular smooth muscle (VSM)contraction (vasospasm) is one of the crucial phenomena which cause cardiac angina and myocardial infarction. We previously found that sphingosylphosphorylcholine (SPC) as an upstream mediator for the abnormal pathway through the activation of Fyn, a member of Src family tyrosine kinase. The localization of Fyn in cholesterol-enriched membrane microdomain, lipid rafts, suggest the essential roles of membrane lipid rafts in abnormal contraction. Therefore, we investigated the relationship between lipid rafts and SPC-induced Ca^<2+>-sensitization of VSM. In addition we screened novel compounds which could inhibit SPC-induced Ca^<2+>-sensitization. Some newly found compounds would be the candidates for novel functional food for vasospasm.
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