2009 Fiscal Year Final Research Report
Serach for New Targeted Molecules of Cancer Using Pharmacophore Method.
| Project/Area Number |
19590023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Meijo University |
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Principal Investigator |
ITO Chihiro Meijo University, 薬学部, 准教授 (60193497)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 天然資源 / がん標的分子 / ファーマコフォア検索 / アポトーシス誘導活性 / 発がんプロモーション抑制活性 / ヒスタミン放出抑制活性 / 抗酸化活性 / 抗炎症活性 |
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| Research Abstract |
The pharmacophore three-dimentional model was constructed on the basis of the most active flavonoid obtained from plant resources. The database searches using this model and the assay on the biological active compounds were repeated. Based on these experimental results, the better pharmacophore three-dimentional model was reconstructed. Some new information was obtained from the searches for bioactive compounds, too.
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