2009 Fiscal Year Final Research Report
Development of a fat soluble signal molecule for cancer chemotherapy
| Project/Area Number |
19590027
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
WADA Akimori Kobe Pharmaceutical University, 薬学部, 教授 (80158683)
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| Co-Investigator(Kenkyū-buntansha) |
OKITSU Takashi 神戸薬科大学, 薬学部, 助教 (50441209)
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| Co-Investigator(Renkei-kenkyūsha) |
OKANO Toshio 神戸薬科大学, 薬学部, 教授 (20131542)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 癌 / シグナル伝達 / 核内受容体 / 生理活性 / イソプレノイド / 脂溶性リガンド |
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| Research Abstract |
As geranylgeranoic acid (GGA) was considered as an retinoic acid analog, various GGA analogs were efficiently synthesized and their biological activities were evaluated. The combination of conjugate polyene system and the position of methyl substituent played an important role in regulation of gene transcription and apoptosis-inducing activity in HL-60 cells. These high activities would be caused by high binding affinity to the receptors. The results provide useful information on the structure-activity relationship of GGA derivatives as mimic of acyclic retinoic acid analogs for the development of new drugs.
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[Journal Article] Quantification of Fat-soluble Vitamins in Human Breast Milk by Liquid Chromatography-tandem Mass Spectrometory2007
Author(s)
M. Kamao, N. Tsugawa, Y. Suhara, A. Wada, T. Mori, K. Murata, R. Nishino, T. Ukita, K. Uenishi, K. Tanaka, T. Okano
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Journal Title
J. Chromatography B 859
Pages: 192-200
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