2009 Fiscal Year Final Research Report
Search for the Activating Substances of Nuclear Receptors as Regulator of Cholesterol Catabolism from Liverworts and Mushrooms
| Project/Area Number |
19590029
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
HASHIMOTO Toshihiro Tokushima Bunri University, 薬学部, 教授 (10075955)
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| Co-Investigator(Kenkyū-buntansha) |
UMEYAMA Akemi 徳島文理大学, 薬学部, 准教授 (40160329)
YOSHIKAWA Kazuko 徳島文理大学, 薬学部, 助教 (40166921)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 生薬 / 天然物化学 |
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| Research Abstract |
Recently, the mechanisms of the regulator of cholesterol catabolism by the activation of liver X receptor (LXR) and farnesoid X receptor (FXR) were found. The activating substances of LXR and FXR were searched from liverworts and mushrooms. We identified a macrocylic bis(bibenzyl), riccardin C from the liverwort Blasia pusilla. Riccardin C functions as LXR α selective agonist. Riccardin C increases plasma HDL level without elevating triglyceride level in mice. We identified marchantins A and E from the liverwort Marchantia polymorpha as FXR agonist.
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