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2008 Fiscal Year Final Research Report

Basic study for development of multi imaging system of redox-related information in tumors

Research Project

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Project/Area Number 19590050
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Physical pharmacy
Research InstitutionSojo University

Principal Investigator

TAKESHITA Keizo  Sojo University, 薬学部, 教授 (70175438)

Co-Investigator(Kenkyū-buntansha) MASUMIZ Toshiki  崇城大学, 薬学部, 准教授 (30412737)
OKAZAKI Shoko  崇城大学, 薬学部, 助教 (40435152)
ANZAI Kazunori  放射線医学総合研究所, 研究員 (70128643)
Co-Investigator(Renkei-kenkyūsha) MASUMIZU Toshiki  崇城大学, 薬学部, 准教授 (30412737)
OKAZAKI Shoko  崇城大学, 薬学部, 助教 (40435152)
ANZAI Kazunori  放射線医学総合研究所, 研究員 (70128643)
Project Period (FY) 2007 – 2008
Keywords生物物理化学
Research Abstract

がんの放射線療法において、酸素分圧とグルタチオン濃度は治療効果を左右する。両者を同一個体で評価する方法を、電子スピン共鳴(ESR)画像解析法を用いて開発した。グルタチオン濃度に関係したレドックスは、ニトロキシルラジカルをプローブとして評価した。3次元ESR画像化法を用いてレドックスプローブと酸素分圧プローブの分布を同一マウスで得る方法を開発した。

  • Research Products

    (11 results)

All 2009 2008 2007

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (7 results)

  • [Journal Article] Relaxation Rates for Spirocyclohexyl Nitroxyl Radicals are Suitable for Interspin Distance Measurements at Temperatures up to about 125 K 02009

    • Author(s)
      Velavan Kathirvelu, Christopher Smith, Christopher Parks, Md. Abdul Mannan, Yozo Miura, Keizo Takeshita, Sandra S. Eaton, and Gareth R. Eaton
    • Journal Title

      Chemical Communications (4)

      Pages: 454-456

    • Peer Reviewed
  • [Journal Article] Enzymatic reduction-resistant nitroxyl spin probes with spirocyclohexyl rings2007

    • Author(s)
      Shoko Okazaki, Md. Abdul Mannan, Keijiro Sawai, Toshiki Masumizu, Yozo Miura,and Keizo Takeshita
    • Journal Title

      Free Radic. Res 41(10)

      Pages: 1069-1077

    • Peer Reviewed
  • [Journal Article] Polymeric micelles of zinc protoporphyrin for tumor targeted delivery based on EPR effect and singlet oxygen generation2007

    • Author(s)
      Arun K. Iyer, Khaled Greish, Takahiro Seki, Shoko Okazaki, Jun Fang, Keizo Takeshita, Hiroshi Maeda
    • Journal Title

      J. Drug Target 15(7-8)

      Pages: 496-506

  • [Journal Article] Scandium ion-accelerated scavenging reaction of cumylperoxyl radical by a cyclic nitroxyl radical via electron transfer2007

    • Author(s)
      Ikuo Nakanishi, Kumiko Kawaguchi, Kei Ohkubo, Tomobori Kawashima, Sushma Manda, Hideko Kanazawa, Keizo Takeshita, Kazunori Anzai, Toshihiko Ozawa, Shunichi Fukuzumi, and Nobuo Ikota
    • Journal Title

      Chem. Lett 36(3)

      Pages: 378-379

    • Peer Reviewed
  • [Presentation] 高血圧モデルマウスにおいてアシル保護ヒドロキシルアミンプローブACPを用いたin vivo ESR法で観測された生体レドックスの変化2009

    • Author(s)
      岡崎祥子, 立花葉子, 古賀由香里, 竹下啓蔵
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      20090326-28日
  • [Presentation] アシル保護プローブを用いたin vivo ESRによる病態モデルマウスのレドックス評価2008

    • Author(s)
      岡崎祥子, 立花葉子, 久保初美, 竹下啓蔵
    • Organizer
      第25回日本薬学会九州支部大会
    • Place of Presentation
      延岡
    • Year and Date
      20081206-07
  • [Presentation] Evaluation of Redox status of Disease Model Mice by in vivo EPR Spcctroscopy with Acyl-ProtectedHydroxylamine Probes2008

    • Author(s)
      Shoko Okazaki, Yoko Tachibana, Yukari Koga, Keizo Takeshita
    • Organizer
      Biomedical redox navigation: EPR2008
    • Place of Presentation
      Fukuoka
    • Year and Date
      20080927-30
  • [Presentation] Radical reduction by polyphenols irradiated with ultraviolet light2007

    • Author(s)
      Shoko Okazaki, Yukari Koga, Toshiki Masumizu and Keizo Takeshita
    • Organizer
      A Joint Conference of the International Symposium on Electron Spin Science and the 46th Annual Meeting of the Society of Electron Spin Sciences and Technology
    • Place of Presentation
      Shizuoka
    • Year and Date
      20071106-09
  • [Presentation] Radical reduction by phenolic compounds irradiated with ultraviolet light2007

    • Author(s)
      Shoko Okazaki, Yukari Koga, Toshiki Masumizu and Keizo Takeshita
    • Organizer
      4th JSPS Core-to-Core Seminar: International In Vivo Redox Symposium
    • Place of Presentation
      Shizuoka
    • Year and Date
      20071104-05
  • [Presentation] 新規ニトロキシルスピンプローブの酵素的還元回避能と活性酸素との反応性の検討2007

    • Author(s)
      岡崎祥子, Md Abdul Mannan、増水章季, 三浦洋三, 竹下啓蔵
    • Organizer
      第29回日本フリーラジカル学会/日本過酸化脂質・フリーラジカル学会第31回大会 合同学会
    • Place of Presentation
      名古屋
    • Year and Date
      20070608-10
  • [Presentation] Piperidine spinprobes with spirocyclohexyl rings: resistance to enzymatic reduction and reactivity with oxygen radicals2007

    • Author(s)
      Keizo Takeshita, Shoko Okazaki, Md. Abdul Mannan, Toshiki Masumizu, Yozo Miura
    • Organizer
      A Joint Conference of the 12th In Vivo EPR Spectroscopy & Imaging and the 9th International EPR Spin Trapping/Spin Labeling
    • Place of Presentation
      Chicago, IL. U.S.A
    • Year and Date
      20070429-0503

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Published: 2010-06-10   Modified: 2016-04-21  

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