2009 Fiscal Year Final Research Report
Study on metabolic control and intracellular transport of phospholipids
| Project/Area Number |
19590068
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
KUGE Osamu Kyushu University, 大学院・理学研究院, 教授 (30177977)
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| Co-Investigator(Kenkyū-buntansha) |
KITADA Sakae 九州大学, 大学院・理学研究院, 助教 (20284482)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 生体膜 / リン脂質 / ホスファチジルセリン / カルジオリピン / ミトコンドリア |
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| Research Abstract |
Metabolic control and intracellular transport of phospholipids are essential events for membrane biogenesis in eukaryotes. The synthesis of phosphatidylserine (PS), one of major phospholipids in mammalian cells, occurs in the endoplasmic reticulum, and many of nascent PS are transported into mitochondria. In this study, to elucidate regulatory mechanisms of PS biosynthesis we purified human PS synthase 1 and 2. Furthermore, we showed that a mitochondrial protein (designated as mitocoil), which is suggested to be involved in PS transport into mitochondria, regulates mitochondrial morphology
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[Journal Article] The AAA+ ATPase ATAD3A controls mitochondrial dynamics at the interface of the inner and outer membranes.2010
Author(s)
Gilquin, B., Taillebourg, E., Cherradi, N., Hubstenberger, A., Gay, O., Merle, N., Assard, N., Fauvarque, M.-O., Tomohiro, S., Kuge, O., Baudier, J.
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Journal Title
Mol. Cell Biol. 30
Pages: 1984-1996
Peer Reviewed
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[Journal Article] Identification of a novel gene involved in cardiolipin metabolism and mitochondrial morphology in the yeast Saccharomyces cerevisiae.2009
Author(s)
Kuroda, T., Tani, M., Moriguchi, A., Tokunaga, S., Higuchi, T., Kitada, S., Kuge, O.
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Journal Title
Chemistry and Physics of Lipids 160
Pages: 29
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