2009 Fiscal Year Final Research Report
Memory-enhancing effects of flavonoids
| Project/Area Number |
19590086
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Musashino University |
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Principal Investigator |
ABE Kazuho Musashino University, 薬学研究所, 教授 (60202660)
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| Project Period (FY) |
2007 – 2009
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| Keywords | フラボノイド / フィセチン / 海馬 / 長期増強 / MAPキナーゼ / ERK / 記憶 / 認知症 |
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| Research Abstract |
To find a new therapy for treatment of memory impairment in patients with senile dementia, this study investigated mechanisms underlying the memory-enhancing effect of fisetin, a flavonoid, and found that fisetin promoted hippocampal synaptic plasticity by activating ERK signal in a cAMP-independent manner. In addition, a structure-activity study provided a new compound that promotes hippocampal synaptic plasticity with higher potency than fisetin.
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