2009 Fiscal Year Final Research Report
Relation of the cytotoxic effect of Mycobacterium tuberculosis on host cells and the signal transduction from interlukin 1 (IL-1) receptor and IL-1R related receptors
| Project/Area Number |
19590122
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
TAKII Takemasa Nagoya City University, 大学院・薬学研究科, 准教授 (80244573)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 微生物 / 感染症学 |
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| Research Abstract |
Mycobacterium species possess lipid rich cell wall, which is well known to induce innate immune response in host cells through toll like receptors(TLRs). The signal transduction form the receptor is partly shared with it form interleukin 1 receptor (IL-1R). We compared the inducing activity of NF-kB between M. tuberculosis and its vaccine strain BCG. The activity related to their virulence.
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[Journal Article] Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis.2009
Author(s)
Horita Y, Takii T, Chiba T, Kuroishi R, Maeda Y, Kurono Y, Inagaki E, Nishimura K, Yamamoto Y, Abe C, Mori M, Onozaki K.
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Journal Title
Bioorg Med Chem Lett. 19(22)
Pages: 6313-6
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[Journal Article] Comparable studies of immunostimulating activities in vitro among Mycobacterium bovis bacillus Calmette-Guerin (BCG) substrains.2009
Author(s)
Hayashi D, Takii T, Fujiwara N, Fujita Y, Yano I, Yamamoto S, Kondo M, Yasuda E, Inagaki E, Kanai K, Fujiwara A, Kawarazaki A, Chiba T, Onozaki K.
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Journal Title
FEMS Immunol Med Microbiol. 56(2)
Pages: 116-28
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[Journal Article] Cigarette smoke condensate upregulates the gene and protein expression of proinflammatory cytokines in human fibroblast-like synoviocyte line.2008
Author(s)
Shizu M, Itoh Y, Sunahara R, Chujo S, Hayashi H, Ide Y, Takii T, Koshiko M, Chung SW, Hayakawa K, Miyazawa K, Hirose K, Onozaki K.
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Journal Title
J Interferon Cytokine Res. 28(8)
Pages: 509-21
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[Journal Article] Dihydrotestosterone inhibits tumor necrosis factor alpha induced interleukin-1alpha mRNA expression in rheumatoid fibroblast-like synovial cells.2007
Author(s)
Itoh Y, Hayashi H, Xu J, Takii T, Miyazawa K, Ariga H, Akahoshi T, Waguri-Nagaya Y, Otsuka T, Okamoto T, Onozaki K.
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Journal Title
Biol Pharm Bull. 30(6)
Pages: 1140-3
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