2009 Fiscal Year Final Research Report
The role of DNA methylation in cadmium-induced anti-carcinogenesis
| Project/Area Number |
19590131
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Hiroshima International University |
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Principal Investigator |
TAKIGUCHI Masufumi Hiroshima International University, 薬学部, 准教授 (90330753)
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| Project Period (FY) |
2007 – 2009
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| Keywords | カドミウム / エピジェネティックス / がん / DNA / メチル化 |
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| Research Abstract |
Cadmium (Cd) is a carcinogenic metal in humans and rodents. Cd in certain instances can also be anti-carcinogenic. In this study, Cd is an effective inhibitor of DNA methyltransferase, controlled DNA methylation status, and kinetic studies indicated the mechanism is via interference with enzyme-DNA interaction. The enzyme-DNA binding site may be Pro-Cys in catalytic site of enzyme. In addition, Cd inhibited cell invasion activity via inhibition of MMP2 activity. This result proposed one of the new mechanisms of cadmium-induced anti-carcinogenesis.
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