2008 Fiscal Year Final Research Report
Dosage schedule based on pharmacokinetic and pharmacodynamic interaction of immunosuppressants
| Project/Area Number |
19590141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
YANO Ikuko Kyoto University, 薬学研究科, 准教授 (50273446)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUDO Masahide 京都大学, 医学研究科, 助教 (60437233)
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| Project Period (FY) |
2007 – 2008
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| Keywords | 移植・再生医療 / 薬理学 / 薬剤反応性 |
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| Research Abstract |
新規免疫抑制剤であるエベロリムス体内動態についてラットを用いて検討した結果、小腸での高い初回通過効果のためバイオアベイラビリティが低いこと、併用したタクロリムスとは相互作用しないが、シクロスポリンとは小腸部位で相互作用を起こすことが判明した.さらに、タクロリムス併用膵島移植患者では薬物間相互作用が期待できないため、エベロリムスではシロリムスに比べて約3倍の投与量を必要とすることが示唆された.
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Research Products
(35 results)
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[Journal Article] Prospective evaluation of the Bayesian method for individualizing tacrolimus dose early after living-donor liver transplantation2009
Author(s)
Fukudo, M., Yano, I., Shinsako, K., Katsura, T., Takada, Y., Uemoto, S., Inui, K.
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Journal Title
J. Clin. Phamacol (in press)
Peer Reviewed
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[Journal Article] Population analysis of myelosuppression profiles using routine clinical data after combination cancer chemotherapy2009
Author(s)
Yano, Y., Kodawara, T., Hongo, H., Yano, I., Kishi, Y., Takahashi, J., Inui, K
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Journal Title
Peer Reviewed
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[Journal Article] A larger dosage is needed for everolimus than sirolimus to maintain the same blood concentration in two pancreatic islet transplant patients with tacrolimus. Drug Metab.2009
Author(s)
Sato, E., Yano, I., Shimomura, M., Masuda, S., Toshiya Katsura, T., Matsumoto, S., Okitsu, T., Iwanaga, Y., Shinji Uemoto, S., Inui , K
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Journal Title
Pharmacokinet 24(2)
Pages: 175-179
Peer Reviewed
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[Journal Article] A retrospective analysis of vancomycin pharmacokinetics in Japanese cancer and non-cancer patients based on routine trough monitoring data. Biol2009
Author(s)
Omote, S., Yano, Y., Hashida, T., Masuda, S., Yano, I., Katsura, T., Inui, K
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Journal Title
Pharm. Bull 32(1)
Pages: 99-104
Peer Reviewed
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[Journal Article] Impact of MDR1 and CYP3A5 on the oral clearance of tacrolimus and tacrolimus-related renal dysfunction in adult living-donor liver transplant patients2008
Author(s)
Fukudo, M., Yano, I., Yoshimura, A., Masuda, S., Uesugi, M., Hosohata, K., Katsura, T., Ogura, Y., Oike, F., Takada, Y., Uemoto, S., Inui, K
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Journal Title
Pharmacogenet. Genomics 18(5)
Pages: 413-423
Peer Reviewed
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[Journal Article] Effect of intestinal and hepatic first-pass extraction on the pharmacokinetics of everolimus in rats2008
Author(s)
Yokomasu, A., Yano, I., Sato, E., Masuda, S., Toshiya Katsura, T., Inui, K
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Journal Title
Drug Metab. Pharmacokinet 23(6)
Pages: 469-475
Peer Reviewed
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[Journal Article] Pharmacokinetics andpharmacodynamics of paclitaxel with carboplatin or gemcitabine and effects of CYP3A5 and MDR1 polymorphisms in patients with urogenital cancers2007
Author(s)
Jiko, M., Yano, I., Sato, E., Takahashi, K., Motohashi, H., Masuda, S., Okuda, M., Ito, N., Nakamura, E., Segawa, T., Kamoto, T., Ogawa, O., Inui, K
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Journal Title
Int. J. Clin. Oncol 12(4)
Pages: 284-290
Peer Reviewed
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[Journal Article] Distinct effects of omeprazole and rabeprazole on the tacrolimus blood concentration in a kidney transplant recipient. Drug Metab2007
Author(s)
Takahashi, K., Yano, I., Fukuhara, Y., Katsura, T., Takahashi, T., Ito, N., Yamamoto, S., Ogawa, O., Inui, K
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Journal Title
Pharmacokinet 22(6)
Pages: 441-444
Peer Reviewed
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