2009 Fiscal Year Final Research Report
Predictors of the response to therapy targeting the cutaneous microbiota in patient with atpic dermatitis
| Project/Area Number |
19590164
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Meiji Pharmaceutical University |
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Principal Investigator |
SUGITA Takashi Meiji Pharmaceutical University, 薬学部, 准教授 (10312076)
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| Project Period (FY) |
2007 – 2009
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| Keywords | アトピー性皮膚炎 / 皮膚常在微生物叢 / 反応予測因子 / 診断 / 治療 |
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| Research Abstract |
Fungal cutaneous microbiota, Malasszia is one of exacerbating factor of atopic dermatitis. The symptom is improved when the microorganisms is eradicated by antifungal agents. This study investigated the predictors of the response to antifungal therapy. We found that an anti-Malassezia-specific IgE antibody and the cutaneous Malassezia colonization level affected the response to antifungal therapy. Quantitative methods for analyzing these two factors were also established.
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[Journal Article] A revised culture based identification system for Malassezia.2007
Author(s)
Kaneko T, Makimura K, Abe M, Shiota R, Nakamura Y, Kano R, Hasegawa A, Sugita T, Shibuya S, Watanabe S, Yamaguchi H, Abe S, Okamura N.
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Journal Title
J. Clin. Microbiol. 45
Pages: 3737-42
Peer Reviewed
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