2009 Fiscal Year Final Research Report
Biological roles of the thyrostimulin, the novel glycoprotein hormone from pituitary
| Project/Area Number |
19590245
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Nagoya University |
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Principal Investigator |
NAGASAKI Hiroshi Nagoya University, 大学院・医学系研究科, 寄附講座講師 (30420384)
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| Co-Investigator(Kenkyū-buntansha) |
HAMADA Youji 名古屋大学, 大学院・医学系研究科, 寄附講座准教授 (20293706)
OOISO Yutaka 名古屋大学, 大学院・医学系研究科, 教授 (40203707)
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| Project Period (FY) |
2007 – 2009
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| Keywords | サイロスティムリン / 下垂体 / 甲状腺 / ACTH / サイトカイン |
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| Research Abstract |
Thyrostimulin is a novel glycoprotein hormone from anterior pituitary that regulates various endocrine organs including thyroid, adrenal gland, and reproductive glands. We found inflammatory cytokines up-regulated GPB5 (one of the subunit composing heterodimeric thyrostimulin) that suggest the hormone is involved in the stress response. Also GPB5 co-localize with ACTH in the anterior pituitary cells in higher mammalian species including ovine, porcine, bovine, and human.
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