2009 Fiscal Year Final Research Report
Research on substance P receptor as a novel target for antidepressant therapy using neuroimaging techniques
| Project/Area Number |
19590261
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
SUZUKI Hidenori Nippon Medical School, 大学院・医学研究科, 教授 (30221328)
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| Co-Investigator(Kenkyū-buntansha) |
OKUBO Yoshiro 日本医科大学, 大学院・医学研究科, 教授 (20213663)
NAGANO Masatoshi 日本医科大学, 医学部, 講師 (60271350)
IKEDA Yumiko 日本医科大学, 医学部, 助教 (10386154)
SAKAI Atsushi 日本医科大学, 医学部, 助教 (30386156)
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| Co-Investigator(Renkei-kenkyūsha) |
SUHARA Tetsuya 独立行政法人放射線医学研究所, 分子イメージング, グループリーダー (90216490)
ITO Hiroshi 独立行政法人放射線医学研究所, 分子イメージング, グループリーダー (20360357)
MATSUDA Tetsuya 玉川大学, 学術研究所, 講師 (30384720)
YAHATA Noriaki 東京大学, 医学系研究科, 特任助教 (70409150)
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| Project Period (FY) |
2007 – 2009
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| Keywords | うつ・不安動物モデル / 機能的磁気共鳴撮像法 / 気分障害 / サブスタンスP受容体 / セロトニン神経系 / 選択的セロトニン再取り込み阻害薬 / 認知機能 / 陽電子断層撮像法 |
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| Research Abstract |
NK-1 receptors in the human brain were visualized and quantified using ^<18>F-FE-SPA-RQ with PET. The prefrontal and the limbic cortices, the regions responsible for the depression and the anxiety disorders, expressed substantial amount of NK-1 receptors. An fMRI study revealed neural substrates influenced by an antidepressant during the cognitive task performance. The combined application of both noninvasive neuroimaging techniques could be of great utility for development and evaluation of drugs to treat psychiatric disorders.
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[Journal Article] Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders.2008
Author(s)
Yamasaki N, Maekawa M, Kobayashi K, Kajii Y, Maeda J, Soma M, Takao K, Tanda K, Ohira K, Toyama K, Kanzaki K, Fukunaga K, Sudo Y, Ichinose H, Ikeda M, Iwata N, Ozaki N, Suzuki H, Higuchi M, Suhara T, Yuasa S, Miyakawa T
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Journal Title
Peer Reviewed
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[Journal Article] Quantitative analysis of NK1 receptor in the human brain using PET with 18F-FE-SPA-RQ.2008
Author(s)
Okumura M, Arakawa R, Ito H, Seki C, Takahashi H, Takano H, Haneda E, Nakao R, Suzuki H, Suzuki K, Okubo Y, Suhara T
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Journal Title
J Nucl Med 49
Pages: 1749-1755
Peer Reviewed
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