2008 Fiscal Year Final Research Report
The molecular mechanisms of transcriptional and translational control of stress responses in pancreatic β cells
| Project/Area Number |
19590300
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Nihon University (2008)
Tohoku University (2007) |
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Principal Investigator |
ISHIHARA Hisamitsu Nihon University, 医学部, 医学部 (60361086)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Suguru 東北大学, 国際高等融合領域研究所, 助教授 (70451614)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAGUCHI Suguru 東北大学, 国際高等融合領域研究所, 助教授 (70451614)
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| Project Period (FY) |
2007 – 2008
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| Keywords | 糖尿病 / 膵島 / シグナル伝達 |
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| Research Abstract |
膵β細胞において翻訳(タンパク合成)抑制因子4E-BP1が、ストレス応答のマスター転写因子であるATF4の活性化によって発現増加することを明らかにした。また、4E-BP1欠損マウスβ細胞は、小胞体ストレスに対し脆弱になっていることを突き止めた。これらのことから、小胞体ストレス下のβ細胞では、タンパク合成を抑制しておくことが生存にとっては利であり、そのために4E-BP1の発現が誘導されるものと考えられた。
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Research Products
(25 results)
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[Journal Article] Minokoshi Y, Oka Y. Regulation of Pancreatic β cell Mass by Neuronal Signals from the Liver2008
Author(s)
Imai J, Katagiri H, Yamada T, Ishigaki Y, Suzuki T, Kudo H, Uno K, Hasegawa Y, Gao J, Kaneko K, Ishihara H, Niijima A, Nakazato M, Asano T
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Journal Title
Science 322
Pages: 1250- 1254
Peer Reviewed
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[Journal Article] ATF4-mediated induction of 4E-BP1 contributes to pancreatic β cell survival under endoplasmic reticulum stress2008
Author(s)
Yamaguchi S, Ishihara H, Yamada T, Tamura A, Usui M, Tominaga R, Munakata Y, Satake C, Katagiri H, Tashiro F, Aburatani H, Tsukiyama-Kohara K, Miyazaki J, Sonenberg N, Oka Y
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Journal Title
Cell Metab 7
Pages: 269-276
Peer Reviewed
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[Journal Article] Impact of plasma oxidized low-density lipoprotein removal on atherosclerosis2008
Author(s)
Ishigaki Y, Katagiri H, Gao J, Yamada T, Imai J, Hasegawa Y, Kaneko K, Ogihara T, Ishihara H, Sata Y, Takikawa K, Nishimichi N, Matsuda, H., Sawamura, T., Oka, Y
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Journal Title
Circulation 118
Pages: 75-83
Peer Reviewed
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[Journal Article] Bone marrow (BM) transplantation promotes β-cell regeneration after acute injury through BM cell mobilization2007
Author(s)
Hasegawa Y, Ogihara T, Yamada T, Ishigaki Y, Imai J, Uno K, Gao J, Kaneko K, Ishihara H, Sasano H, Nakauchi H, Oka Y, Katagiri H
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Journal Title
Endocrinology 148
Pages: 2006-2015
Peer Reviewed
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[Journal Article] Carotid arterial elasticity is a sensitive atherosclerosis value reflecting visceral fat accumulation in obese subjects
Author(s)
Tokita A, Ishigaki Y, Okimoto H, Hasegawa H, Koiwa Y, Kato M, Ishihara H, Hinokio Y, Katagiri H, Kanai H, Oka Y
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Journal Title
Atherosclerosis (in press)
Peer Reviewed
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