2009 Fiscal Year Final Research Report
Novel molecular target therapy for pancreatic cancer
| Project/Area Number |
19590317
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Osaka City University |
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Principal Investigator |
NAKATA Bunzo Osaka City University, 大学院・医学研究科, 准教授 (60271178)
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| Co-Investigator(Kenkyū-buntansha) |
YASHIRO Masakazu 大阪市立大学, 大学院・医学研究科, 准教授 (60305638)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 膵癌 / DNA array / 分子標的治療 / 代謝拮抗剤 |
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| Research Abstract |
There was a positive correlation between the clinical efficacy by gemcitabine and the expression of deoxycytidine kinase in pancreatic cancer. The majority of pancreatic cancers showed overexpression of HER2 and/or EGFR. Consequently, lapatinib, a molecular targeting agent for both of HER2 and EGFR, may be effective for pancreatic cancer. In vitro and in vivo experimental results demonstrated the substantial anti-tumor effect for pancreatic cancer by lapatinib alone and combined with S-1. It was suggested that the anti-tumor effect of lapatinib was associated with HER2 expression.
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Research Products
(12 results)
