2009 Fiscal Year Final Research Report
Analysis of androgen actions in human breast carcinoma
| Project/Area Number |
19590339
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Tohoku University |
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Principal Investigator |
SUZUKI Takashi Tohoku University, 大学院・医学系研究科, 教授 (10261629)
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| Co-Investigator(Renkei-kenkyūsha) |
SASANO Hironobu 東北大学, 大学院・医学系研究科, 教授 (50187142)
HAYASHI Shin-ichi 東北大学, 大学院・医学系研究科, 教授 (60144862)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 乳癌 / アンドロゲン / アロマターゼ |
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| Research Abstract |
Previous studies have demonstrated that androgens exert anti-proliferative effects in the breast carcinoma, but the detailed mechanisms remain unclear. Results of our present study demonstrated that (1) androgen actions were markedly suppressed by estrogens in the breast carcinoma, (2) an estrogen-producing enzyme, aromatase, also plays as a negative regulator of intratumoral androgen production, (3) androgen actions were increased in the breast carcinoma treated with an aromatase inhibitor, and (4) 17βHSD2 was identified as an androgen-induced gene in the breast carcinoma, which was involved in the anti-proliferative effects of androgens on the breast carcinoma.
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[Journal Article] Increased intratumoral androgens in human breast carcinoma following aromatase inhibitor exemestane treatment2010
Author(s)
Takagi K, Miki Y, Nagasaki S, Hirakawa H, Onodera Y, Akahira J, Ishida T, Watanabe M, Kimijima I, Hayashi S, Sasano H, Suzuki T.
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Journal Title
Endocr Relat Cancer 17
Pages: 415-30
Peer Reviewed
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[Journal Article] Amyloid precursor protein is a primary androgen target gene that promotes prostate cancer growth2009
Author(s)
Takayama K, Tsutusumi S, Suzuki T, Horie-Inoue K, Ikeda K, Kaneshiro K, Fujimura T, Kumagai J, Urano T, Sakaki Y, Shirahige K, Sasano H, Takahashi S, Kitamura T, Ouchi Y, Aburatani H, Inoue S.
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Journal Title
Cancer Res. 69
Pages: 137-142
Peer Reviewed
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[Journal Article] Intratumoral concentration of sex steroids and expression of sex steroid-producing enzymes in ductal carcinoma in situ of human breast2008
Author(s)
Shibuya R, Suzuki T, Miki Y, Yoshida K, Moriya T, Ono K, Akahira JI, Ishida T, Hirakawa H, Evans DB, Sasano H.
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Journal Title
Endocr Relat Cancer 15
Pages: 113-124
Peer Reviewed
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[Journal Article] Intratumoral estrogens and estrogen receptors in human non-small cell lung carcinoma2008
Author(s)
Niikawa H, Suzuki T, Miki Y, Suzuki S, Nagasaki S, Akahira J, Honma S, Evans DB, Hayashi S, Kondo T, Sasano H.
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Journal Title
Clin Cancer Res. 14(14)
Pages: 4417-26
Peer Reviewed
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[Journal Article] Aromatase localization in human breast cancer tissues : possible interactions between intratumoral stromal and parenchymal cells2007
Author(s)
Miki Y, Suzuki T, Tazawa C, Yamaguchi Y, Kitada K, Honma S, Moriya T, Hirakawa H, Evans DB, Hayashi S, Ohuchi N, Sasano H.
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Journal Title
Cancer Res. 67
Pages: 3945-54
Peer Reviewed
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