Clinicopathologic and biologic study oriented for the new classification of EBV-associated lymphoproliferative disorder

2008 Fiscal Year Final Research Report

• Project/Area Number: 19590344
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Nagoya University
• Principal Investigator: NAKAMURA Shigeo Nagoya University, 大学院・医学系・研究科, 教授 (80180363)
• Project Period (FY): 2007 – 2008
• Keywords: 病理 / 癌 / 加齢

Research Abstract

加齢性EBV関連B細胞リンパ増殖異常症は、本邦より我々が世界に初めて発信した疾患概念である。世界に類例なき高齢化に向かいつつある本邦において、初めて認識が可能であった疾患である。2008年9月に公刊されたWHO分類第4版に正式な項目として掲載された。本疾患の正式掲載以降、欧米でも同様の疾患の報告とともに、加齢に伴う免疫機能の低下の関与とその臨床病理学的重要性が急速に指摘されつつある。当該期間において、これらEBV関連リンパ増殖症の免疫監視機構の解明を含む体系的理解、新分類の画定、さらに新たな治療法、予防法の開発を目指して研究を遂行した。

Research Products

• [Journal Article] Age-related EBV-associated B-cell lymphoproliferative disorders: comparison with EBV-positive classical Hodgkin lymphoma in elderly patients (2008)
  • Author(s): Asano N, Yamamoto K, Tamaru JI, Oyama T, Ishida F, Ohshima K, Yoshino T, Nakamura N, Mori S, Yoshie O, Shimoyama Y, Morishima Y, Kinoshita T, Nakamura S.
  • Journal Title: Blood
  • Peer Reviewed
• [Journal Article] Clinical differences between nasal and extranasal NK/T cell lymphoma: a study of 136 cases from the International Peripheral T cell Lymphoma Project (2008)
  • Author(s): Au WY, Weisenburger DD, Intragumtornchai T, Nakamura S, Kim WS, Sng I, Vose J, Armitage JO, Liang R.
  • Journal Title: Blood 48(2) Pages: 39-45
  • Peer Reviewed
• [Journal Article] Post-transplant plasmacytoma without Epstein-Barr virus infection occurring rapidly after unrelated allogeneic bone marrow transplantation (2008)
  • Author(s): Kawakami K, Miyanishi S, Nakano Y, Mitani H, Nakao M, Murata T, Baba Y, Nakamura S.
  • Journal Title: Int J Hematol
  • Peer Reviewed
• [Journal Article] "Follicular Variant" of Hyaline-vascular Type of Castleman's Disease : Histopathological and Immunohistochemical Study of 11 Cases (2008)
  • Author(s): Kojima M, Shimizu K, Ikota H, Ohno Y, Motoori T, Itoh H, Masawa N, Nakamura S.
  • Journal Title: J Clin Exp Hematop 48(2) Pages: 39-45
  • Peer Reviewed
• [Journal Article] Japanese phase II study of (90)Y-ibritumomab tiuxetan in patients with relapsed or refractory indolent B-cell lymphoma (2008)
  • Author(s): Tobinai K, Watanabe T, Ogura M, Morishima Y, Hotta T, Ishizawa K, Itoh K, Okamoto SI, Taniwaki M, Tsukamoto N, Okumura H, Terauchi T, Nawano S, Matsusako M, Matsuno Y, Nakamura S, Mori S, Ohashi Y, Hayashi M, Endo K.
  • Journal Title: Cancer Sci.
  • Peer Reviewed
• [Journal Article] Cytogenetic abnormality 46,XX,add(21)(q11.2) in a patient with follicular dendritic cell sarcoma (2008)
  • Author(s): Suzuki N, Katsusihma H, Takeuchi K, Nakamura S, Ishizawa K, Ishii S, Moriya T, DeCoteau JF, Miura I, Ichinohasama R.
  • Journal Title: Cancer Genet Cytogenet 186(1) Pages: 54-7
  • Peer Reviewed
• [Journal Article] De novo CD5+ diffuse large B-cell lymphoma : results of a detailed clinicopathological review in 120 patients (2008)
  • Author(s): Yamaguchi M, Nakamura N, Suzuki R, KagamiY, Okamoto M, Ichinohasama R, Yoshino T, Suzumiya J, Murase T, Miura I, Ohshima K, Nishikori M, Tamaru JI, Taniwaki M, Hirano M, Morishima Y, Ueda R, Shiku H, Nakamura S.
  • Journal Title: Haematologica 93(8) Pages: 1195-202
  • Peer Reviewed
• [Journal Article] Retrospective analysis of intravascular large B-cell lymphoma treated with rituximab-containing chemotherapy as reported by the IVL study group in Japan (2008)
  • Author(s): Shimada K, Matsue K, Yamamoto K, Murase T, Ichikawa N, Okamoto M, Niitsu N, Kosugi H, Tsukamoto N, Miwa H, Asaoku H, Kikuchi A, Matsumoto M, Saburi Y, Masaki Y, Yamaguchi M, Nakamura S, Naoe T, Kinoshita T.
  • Journal Title: J Clin Oncol 26(19) Pages: 3189-92
  • Peer Reviewed
• [Journal Article] Nodal T/NK-cell lymphoma of nasal type : a clinicopathological study of six cases (2008)
  • Author(s): Takahashi E, Asano N, Li C, Tanaka T, Shimada K, Shimada S, Yoshino T, Kojima M, Hara K, Eimoto T, Nakamura S.
  • Journal Title: Histopathology 52(5) Pages: 585-96
  • Peer Reviewed
• [Journal Article] Definition, Diagnosis, and Management of Intravascular Large B Cell Lymphoma : Proposals and Perspectives From an International Consensus Meeting (2007)
  • Author(s): Ponzoni M, Ferreri AJ, Campo E, Facchetti F, Mazzucchelli L, Yoshino T, Murase T, Pileri SA, Doglioni C, Zucca E, Cavalli F, Nakamura S.
  • Journal Title: J Clin Oncol 25(21) Pages: 3168-73
  • Peer Reviewed
• [Journal Article] Intravascular large B-cell lymphoma : the heterogeneous clinical manifestations of its classical and hemophagocytosis-related forms (2007)
  • Author(s): Nakamura S, Murase T, Kinoshita T.
  • Journal Title: Haematologica 92(4) Pages: 434-6
  • Peer Reviewed
• [Journal Article] Intravascular large B-cell lymphoma (IVLBCL) : a clinicopathologic study of 96 cases with special reference to the immunophenotypic heterogeneity of CD5 (2007)
  • Author(s): Murase T, Yamaguchi M, Suzuki R, Okamoto M, Sato Y, Tamaru JI, Kojima M, Miura I, Mori N, Yoshino T, Nakamura S.
  • Journal Title: Blood 109(2) Pages: 478-85
  • Peer Reviewed
• [Journal Article] Cytotoxic molecule expression is predictive of prognosis in Hodgkin's-like anaplastic large cell lymphoma (2007)
  • Author(s): Asano N, Suzuki R, Matsuo K, Kagami Y, Ishida F, Tamaru JI, Jin GS, Sato Y Shimoyama Y, Yoshino T, Morishima Y, Nakamura S.
  • Journal Title: Histopathology 50(6) Pages: 705-15
  • Peer Reviewed
• [Book] Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)WHO Classification of Tumours of Haematopietic and Lymphoid Tissues. (2008)
  • Author(s): Isaacson PG, Chott A, Nakamura S, Muller-Hermelink HK, Harris NL, Swerdlow SH.
  • Total Pages: 214-217
  • Publisher: IARS Press, Lyon(Swedlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW eds.)
• [Book] WHO Classification of Tumours of Haematopietic and Lymphoid Tissues(Swedlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW eds.) (2008)
  • Author(s): Nakamura S, Jaffe ES, Swerdlow SH.
  • Total Pages: 243-244
  • Publisher: IARS Press, Lyon
• [Book] WHO Classification of Tumours of Haematopietic and Lymphoid Tissues(Swedlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW eds.) (2008)
  • Author(s): Nakamura S, Ponzoni M, Campo E.
  • Total Pages: 252-253
  • Publisher: IARS Press, Lyon
• [Book] Muller-Hermelink HK, Jaffe ES.Peripheral T-cell lymphoma, not otherwise specified.WHO Classification of Tumours of Haematopietic and Lymphoid Tissues(Swedlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW eds.) (2008)
  • Author(s): Pileri SA, Ralfkiaer E, Weisenburger DD, Nakamura S, Sng I, Nakamura S
  • Total Pages: 306-308
  • Publisher: IARS Press, Lyon