2008 Fiscal Year Final Research Report
Molecular comparison of extranodal and nodal follicular and mantle cell lymphomas
| Project/Area Number |
19590348
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Okayama University |
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Principal Investigator |
YOSHINO Tadashi Okayama University, 大学院・医歯薬学総合研究科, 教授 (70183704)
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| Project Period (FY) |
2007 – 2008
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| Keywords | 悪性リンパ腫 / 非ホジキンリンパ腫 / 濾胞性リンパ腫 / 節外性 / 節性 / 十二指腸 / 濾胞樹状細胞 / 体細胞突然変異 |
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| Research Abstract |
節外性濾胞性リンパ腫、特に十二指腸症例を検索した。その結果、十二指腸濾胞性リンパ腫例は節性と同様免疫グロブリン遺伝子にon-going mutationは認められたが後者に比べて臨床病期の低くAIDの発現が明らかに低率であることを見出した。また、VHのusageではVH4VH5に偏在していいた。これにより、十二指腸濾胞性リンパ腫は節性と同様の分子発生機転を有しつつもMALTリンパ腫に近似した性格を有することを初めて発見した。
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[Journal Article] marginal zone B cell lymphoma of mucosa-associated lymphoid tissue type : case report and review of the literature2008
Author(s)
Doi H, Horiike N, Hiraoka A, Koizumi Y, Yamamoto Y, Hasebe A, Ichikawa S, Yano M, Miyamoto Y, Ninomiya T, Ishimaru Y, Miyagawa M, Takamura K, Kawasaki H, Kozuka T, Maeda T, Yoshino T
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Journal Title
Int J Hematol 23(Epub ahead of print)
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[Journal Article] Duodenal and nodal follicular lymphomas are distinct : The former lacks activation-induced cytidine deaminase (AID) and follicular dendritic cells despite ongoing somatic hypermutations
Author(s)
Takata K, Sato Y,Nakamura N, Kikuti YY, Ichimura K, Tanaka T, Morito T, Tamura M, Oka T, Kondo E, Okada H, Tari A and Yoshino T
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Journal Title
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[Journal Article] Frequent inactivation of A20 in B-cell lymphomas Nature
Author(s)
Motohiro Kato, Masashi Sanada, Itaru Kato, Yasuharu Sato, Junko Takita, Kengo Takeuchi, Akira Niwa, Yuyan Chen, Kumi Nakazaki, Junko Nomoto, Yoshitaka Asakura, Satsuki Muto, Azusa Tamura, Mitsuru Iio, Yoshiki Akatsuka, Yasuhide Hayashi, Hiraku Mori, Takashi Igarashi, Mineo Kurokawa, Shigeru Chiba, Shigeo Mori, Yuichi Ishikawa, Koji Okamoto, Kensei Tobinai, Hiroshi Nakagama, Tatsutoshi Nakahata, Tadashi Yoshino, Yukio Kobayashi, Seishi Ogawa
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Journal Title
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[Journal Article] Systemic IgG4-related lymphadenopathy : Clinical and pathological differences from multicentric Castleman's disease
Author(s)
Sato Y, Kojima M, Takata K, Morito T, Asaoku H, Takeuchi T, Mizobuch Ki, Fujihara M, Kuraoka K, Nakai T,Ichimura K, Tanaka T, Tamura M, Nishikawa Y, Yoshino T
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[Book] WHO classification of Tumours (4th Ed)2008
Author(s)
T. Yoshino, NL. Harris, BN Nathwani, SH Swerdlow, D de Jong, ES Jaffe, G Ott, D Spagnolo Follicular lymphoma
Total Pages
220-226
Publisher
SH Swerdlow, E Campo, NL Harris, ES Jaffe, SA Pileri, H Stein, J Thiele, JW Vardiman(IARC Press, Lyon)
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