Establishment of the diagnostic method using antibody against phosphorylated EGFR for responsiveness to gefitinib therapy of lung cancer patients

2008 Fiscal Year Final Research Report

• Project/Area Number: 19590354
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Oita University
• Principal Investigator: HIJIYA Naoki Oita University, 医学部, 助教 (80305036)
• Co-Investigator(Kenkyū-buntansha): 守山 正胤 大分大学, 医学部, 教授 (90239707)
• Project Period (FY): 2007 – 2008
• Keywords: EGFR / リン酸化 / 肺癌 / Gefitinib / 免疫組織化学

Research Abstract

肺癌に対する抗癌剤であるGefitinibは、よく効く症例がある反面、まったくの無効例や重篤な副作用を発症する症例も多く、その奏効予測因子の同定が求められている。我々はEGFRのリン酸化がGefitinib感受性と高度に相関することを見出した。この知見に基づき、Gefitinib投与前にその奏功性をより簡便、迅速かつ正確に予測する診断法を確立した。

Research Products

• [Journal Article] Phosphorylation status of epidermal growth factor receptor is closely associated with responsiveness to gefitinib in pulmonary adenocarcinoma (2008)
  • Author(s): Hijiya N., Miyawaki M., Kawahara K., Akamine S., Tsuji K., Kadota J., Akizuki S., Uchida T., Matsuura K., Tsukamoto Y., Moriyama M.
  • Journal Title: Hum Pathol 39 Pages: 316-323
  • Peer Reviewed
• [Journal Article] Arpp/Ankrd2, a member of the muscle ankyrin repeat proteins (MARPs), translocates from the I-band to the nucleus after muscle injury (2008)
  • Author(s): Tsukamoto Y., Hijiya N., Yano S., Yokoyama S., Nakada C., Uchida T., Matsuura K., Moriyama M.
  • Journal Title: Histochem Cell Biol 129 Pages: 55-64
  • Peer Reviewed
• [Journal Article] Genotyping of the cagA gene of Helicobacter pylori on immunohistochemistry with East Asian CagA-specific antibody (2008)
  • Author(s): Kanada R., Uchida T., Tsukamoto Y., Nguyen LT., Hijiya N., Matsuura K., Kodama M., Okimoto T., Murakami K., Fujioka T., Yanagisawa S., Moriyama M.
  • Journal Title: Pathol Int 58 Pages: 218-225
  • Peer Reviewed
• [Journal Article] Genome-wide microRNA expression profiling in renal cell carcinoma : significant downregulation of miR-141 and miR-200c (2008)
  • Author(s): Nakada C., Matsuura K., Tsukamoto Y., Tanigawa M., Yoshimoto T., Narimatsu T., Nguyen LT., Hijiya N., Uchida T., Sato F., Mimata H., Seto M., Moriyama M.
  • Journal Title: J Pathol 216 Pages: 418-427
  • Peer Reviewed
• [Journal Article] Genome-wide analysis of DNA copy number alterations and gene expression in gastric cancer (2008)
  • Author(s): Tsukamoto Y., Uchida T., Karnan S., Noguchi T., Nguyen LT., Tanigawa M., Takeuchi I., Matsuura K., Hijiya N., Nakada C., Kishida T., Kawahara K., Ito H., Murakami K., Fujioka T., Seto M., Moriyama M.
  • Journal Title: J Pathol 216 Pages: 471-482
  • Peer Reviewed
• [Journal Article] Enhanced phosphorylation of the epidermal growth factor receptor at the site of tyrosine 992 in esophageal carcinomas (2008)
  • Author(s): Miyawaki M., Hijiya N., Tsukamoto Y., Nakada C., Kawahara K., Moriyama M.
  • Journal Title: APMIS 116 Pages: 1097-1106
  • Peer Reviewed
• [Journal Article] Upregulated expression of cardiac ankyrin-repeated protein in renal podocytes is associated with proteinuria severity in lupus nephritis (2007)
  • Author(s): Matsuura K., Uesugi N., Hijiya N., Uchida T., Moriyama M.
  • Journal Title: Hum Pathol 38 Pages: 410-419
  • Peer Reviewed
• [Journal Article] ARPP protein is selectively expressed in renal oncocytoma, but rarely in renal cell carcinomas (2007)
  • Author(s): Shomori K, Nagashima Y, Kuroda N, Honjo A, Tsukamoto Y., Tokuyasu N., Maeta N., Matsuura K., Hijiya N., Yano S., Yokoyama S., Ito H., Moriyama M.
  • Journal Title: Mod Pathol 20 Pages: 199-207
  • Peer Reviewed
• [Journal Article] Immunohistochemical diagnosis of the cagA-gene genotype of Helicobacter pylori with anti-East Asian CagA-specific antibody (2007)
  • Author(s): Uchida T., Kanada R., Tsukamoto Y., Hijiya N., Matsuura K., Yano S., Yokoyama S., Kishida T., Kodama M., Murakami K., Fujioka T., Moriyama M.
  • Journal Title: Cancer Sci 98 Pages: 521-528
  • Peer Reviewed
• [Journal Article] Aortic root subadventitial hematoma (2007)
  • Author(s): Miyamoto S., Hadama T., Iwata E., Anai H., Sako H., Wada T., Tanaka H., Hamamoto H., Hijiya N.
  • Journal Title: Heart Vessels 22 Pages: 136-138
  • Peer Reviewed
• [Presentation] Phosphorylation status of EGFR is closely associated with responsiveness to gefitinib in pulmonary adenocarcinoma (2007)
  • Author(s): 泥谷直樹
  • Organizer: 第66回日本癌学会総会
  • Place of Presentation: 横浜
  • Year and Date: 20071003-05
• [Presentation] 抗リン酸化EGFR抗体を用いた肺腺癌のGefitinib感受性予測診断法の確立 (2007)
  • Author(s): 泥谷直樹
  • Organizer: 第96回日本病理学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20070313-15