2008 Fiscal Year Final Research Report
Genome-wide analysis of renal cell carcinoma with array-based CGH and transcriptome
Project/Area Number |
19590355
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Human pathology
|
Research Institution | Oita University |
Principal Investigator |
MATSUURA Keiko Oita University, 医学部, 准教授 (00291542)
|
Co-Investigator(Kenkyū-buntansha) |
MORIYAMA Masatsugu 大分大学, 医学部, 教授 (90239707)
|
Project Period (FY) |
2007 – 2008
|
Keywords | アレイCGH / 腎癌 / トランスクリプトーム / 遺伝子解析 / 病型分類 |
Research Abstract |
アレイCGHを用いて腎細胞癌(CCC)の発症にかかわるゲノム異常を検索したところ、特に14番染色体長腕(14q)の欠失が、高悪性度のCCCで高頻度にみられた。さらに網羅的遺伝子発現解析(トランスクリプトーム解析)を行い、ゲノムのコピー数異常が遺伝子発現異常に影響を与えていることを見出した。14qで遺伝子発現低下を示した遺伝子のいくつかは、実際に腎癌で遺伝子の発現が減弱しており、CCCの悪性化に関わる癌関連遺伝子と考えられた。
|
Research Products
(10 results)
-
[Journal Article] Genome-wide microRNA expression profiling in renal cell carcinoma : significant downregulation of miR-141 and miR-200c2008
Author(s)
Nakada C., Matsuura K., Tsukamoto Y., Tanigawa M., Yoshimoto T., Narimatsu T., Nguyen LT., Hijiya N., Uchida T., Sato F., Mimata H., Seto M., Moriyama M.
-
Journal Title
The Journal of Pathology 216
Pages: 418-427
Peer Reviewed
-
[Journal Article] Genome-wide analysis of DNA copy number alterations and gene expression in gastric cancer2008
Author(s)
Tsukamoto Y., Uchida T., Karnan S., Noguchi T., Nguyen LT., Tanigawa M., Takeuchi I., Matsuura K., Hijiya N., Nakada C., Kishida T., Kawahara K., Ito H., Murakami K., Fujioka T., Seto M., Moriyama M.
-
Journal Title
The Journal of Pathology 216
Pages: 471-482
Peer Reviewed
-
[Journal Article] Phosphorylation status of epidermal growth factor receptor is closely associated with responsiveness to gefitinib in pulmonary adenocarcinoma2008
Author(s)
Hijiya N., Miyawaki M., Kawahara K., Akamine S., Tsuji K., Kadota J., Akizuki S., Uchida T., Matsuura K., Tsukamoto Y., Moriyama M.
-
Journal Title
Human Pathology 39
Pages: 316-323
Peer Reviewed
-
-
[Journal Article] Genotyping of the cagA gene of Helicobacter pylori on immunohistochemistry with East Asian CagA-specific antibody2008
Author(s)
Kanada R., Uchida T., Tsukamoto Y., Nguyen LT., Hijiya N., Matsuura K., Kodama M., Okimoto T., Murakami K., Fujioka T., Yanagisawa S., Moriyama M.
-
Journal Title
Pathology International 58
Pages: 218-225
Peer Reviewed
-
[Journal Article] High-resolution analysis of DNA copy number alterations and the gene expression in renal clear cell carcinoma2007
Author(s)
Yoshimoto T, Matsuura K, Karnan S, Tagawa H, Nakada C, Tanigawa M, Tsukamoto Y, Uchida T, Kashima K, Akizuki S, Takeuchi I, Sato F, Mimata H, Seto M, Moriyama M.
-
Journal Title
Journal of Pathology 213
Pages: 392-401
Peer Reviewed
-
-
-
-