2009 Fiscal Year Final Research Report
Molecular Pathologic Analysis for Mechanisms of Multistep Carcinogenesis of Malignant Transformation in Salivary Gland Pleomorphic Adenoma
| Project/Area Number |
19590367
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
NAGAO Toshitaka Tokyo Medical University, 医学部, 教授 (90276709)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 唾液腺 / 癌 / 病理学 / 発癌機構 / 悪性化 / 遺伝子 / 免疫組織化学 |
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| Research Abstract |
To clarify the mechanisms of multistep carcinogenesis of malignant transformation in salivary gland pleomorphic adenoma, pathologic analysis has been done using histologic specimens taken from carcinoma ex pleomorphic adenoma cases. Histologically, malignant component was high-grade carcinoma and in the early stage of development, carcinoma cells proliferated replacing by ductal structures of pre-existing pleomorphic adenoma. Immunohistochemical study revealed that carcinoma component had high proliferative activities and was frequently positive for p53 and HER2/neu. Molecular analysis demonstrated the loss of heterozygosity at p53 microsatellite loci, accompanied by p53 gene point mutation, only in the carcinoma component, but no genetic alterations have been detected in the H-, K-, and N-ras genes. More elaborated studies would be necessary to further progress in this field.
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[Journal Article] Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species2010
Author(s)
Suzuki S, Tanaka T, Poyurovsky MV, Nagano H, Mayama T, Ohkubo S, Lokshin M, Hosokawa H, Nakayama T, Suzuki Y, Sugano S, Sato E, Nagao T, Yokote K, Tatsuno I, Prives C
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Journal Title
Proc Natl Acad Sci U S A 107
Pages: 7461-7466
Peer Reviewed
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[Journal Article] Sebaceous epithelial-myoepithelial carcinoma of the salivary gland: Clinicopathologic and immunohistochemical analysis of 6 cases of a new histologic variant2008
Author(s)
Shinozaki A, Nagao T, Endo H, Kato N, Hirokawa M, Mizobuchi K, Komatsu M, Igarashi T, Yokoyama M, Masuda S, Sano K, Izumi M, Fukayama M, Mukai K
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Journal Title
Am J Surg Pathol 32
Pages: 913-923
Peer Reviewed
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[Journal Article] Correlation between liver metastasis of the colocalization of actin-related protein 2 and 3 complex and WAVE2 in colorectal carcinoma2007
Author(s)
Iwaya K, Oikawa K, Semba S, Tsuchiya B, Mukai Y, Otsubo T, Nagao T, Izumi M, Kuroda M, Domoto H, Mukai K
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Journal Title
Cancer Sci 98
Pages: 992-999
Peer Reviewed
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