Analysis of activation mechanism of HMGA2 gene and its regulating gene-pathways in the progression of lung cancer

2008 Fiscal Year Final Research Report

• Project/Area Number: 19590370
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Kanazawa Medical University
• Principal Investigator: UEDA Yoshimichi Kanazawa Medical University, 医学部, 教授 (50271375)
• Co-Investigator(Kenkyū-buntansha): SAGAWA Motoyasu 金沢医科大学, 医学部, 教授 (70292274)
• Co-Investigator(Renkei-kenkyūsha): SHIMAZAKI Miyako 金沢医科大学, 医学部, 助教 (00440511)
• Project Period (FY): 2007 – 2008
• Keywords: 肺癌 / 扁平上皮癌 / HMGA2 / 上皮間質転換 / 浸潤・転移 / TGFβ / プラコグロビン / Laser captured microddisection

Research Abstract

浸潤性肺扁平上皮癌細胞の上皮間質転換における HMGA2の関与を蛋白ならびに mRNAレベルで示すと共に、HMGA2発現誘導における TGFβ系シグナルの関与とHMGA2発現扁平上皮癌細胞における発現低下遺伝子群( E-cadhelin、Plakoglobin、zonula-occuludens 1(zo-1)、GSK3)、発現亢進遺伝子群(N-cadhelin、Smad4、Snail、cyclin D1、MMP-3、MMP-14、Jagged-1、Ezrin、Aquaporin-5)を選別・検証した。

Research Products

• [Journal Article] Combined evaluation of preoperative FDG uptake on PET, GGO components on CT, and serum CEA Level: Identification of both low and high risk for recurrence in patients with resected T1 lung adenocarcinoma. (2009)
  • Author(s): Kotaro Higashi, Tsutomu Sakuma, Kengo Ito, Seiji Niho, Yoshimichi Ueda, Takeshi, Kobayashi, Ryuzo Sekiguchi, Tomoko Takahashi, Takashi Kato, Hisao Tonami.
  • Journal Title: European Journal of Nuclear Medicine and Molecular Imaging 36 Pages: 373-381
  • Peer Reviewed
• [Journal Article] Down regulation of plakoglobin in soft tissue sarcoma is associated with a higher risk of pulmonary metastasis. (2008)
  • Author(s): Yoshimitsu Kanazawa, Yoshimichi Ueda, Miyako Shimasaki, Shogo Katsuda, Norio Yamamto, Katsuo Tomita,Hiroyuki Tsuchiya.
  • Journal Title: Anticancer Res 28 Pages: 655-664
  • Peer Reviewed
• [Journal Article] Identification of novel genes involved in the synergistic antitumor effect of caffeine in osteosarcoma cells using cDNA macroarray. (2008)
  • Author(s): Sadao Ii, Yoshimichi Ueda, Miyako Shimasaki, Shogo Katsuta, Koutarou Takazawa, Yoshimitsu Kanazawa, Katsuro Tomita, Hiroyuki Tsyuchiya.
  • Journal Title: Anticancer Res 28 Pages: 645-53
  • Peer Reviewed
• [Journal Article] 肺癌病理の Up to Date (2008)
  • Author(s): 上田 善道、島崎 都、東 光太郎、Giafei Guo 、佐藤 勝明、佐川 元保、佐久間 勉、勝田 省吾
  • Journal Title: 金沢医大雑誌 21 Pages: 21-30
  • Peer Reviewed
• [Presentation] Down regulation of plakoglobin in soft tissue sarcoma is associated with a higher risk of pulmonary metastasis. (2008)
  • Author(s): Yoshimitsu Kanazawa , Yoshimichi Ueda , Miyako Shimasaki, Shogo Katsuda, Norio Yamamto, Katsuo Tomita,Hiroyuki Tsuchiya
  • Organizer: The 8^<th>International Conference of Anticancer Research
  • Place of Presentation: in Kos, Greece
  • Year and Date: 20081017-22
• [Presentation] Identific-ation of Novel Genes Involved in the Synergistic Antitumor Effect of Caffeine in Osteosarcoma Cells Using cDNA Macroarray. (2008)
  • Author(s): Sadao Ii, Yoshimichi Ueda, Miyako Shimasaki, Shogo Katsuta, Koutarou Takazawa, Yoshimitsu Kanazawa, Katsuro Tomita, Hiroyuki Tsyuchiya
  • Organizer: The 8^<th>International Conference of Anticancer Research
  • Place of Presentation: in Kos, Greece
  • Year and Date: 20081017-22
• [Presentation] Expression analysis for the identificationof genes involved in acquired resistance to cisplatin in osteosarcoma cells. (2008)
  • Author(s): Koutarou Takazawa, Hiroyuki Tsuchiya, Ueda Yoshimichi, Yoshimitsu Kanazawa, Sadao Ii, Katsuro Tomita
  • Organizer: The 8^<th>International Conference of Anticancer Research
  • Place of Presentation: in Kos, Greece
  • Year and Date: 20081017-22
• [Presentation] ヒト軟部肉腫における新規肺転移抑制遺伝子human plakoglobin遺伝子の同定 (2008)
  • Author(s): 島崎 都、上田善道、佐藤勝明、勝田省吾
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2008051517