2008 Fiscal Year Final Research Report
Malignant transformation of urinary bladder carcinoma cells compared by telomere length measured by original Q-FISH method
| Project/Area Number |
19590375
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Human pathology
|
|---|
| Research Institution | Tokyo Metropolitan Institute of Gerontology |
|---|
Principal Investigator |
IZUMIYAMA Naotaka Tokyo Metropolitan Institute of Gerontology, 東京都老人総合研究所, 助手 (10158751)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Ken-ichi 財団法人東京都高齢者研究・福祉振興財団, 東京都老人総合研究所, 研究員 (60159069)
TAKUBO Kaiyo 財団法人東京都高齢者研究・福祉振興財団, 東京都老人総合研究所, 研究部長 (00154956)
ISHII Akio 財団法人東京都高齢者研究・福祉振興財団, 東京都老人総合研究所, 助手 (60167244)
|
|---|
| Project Period (FY) |
2007 – 2008
|
| Keywords | テロメア / セントロメア / Q-FISH |
|---|
| Research Abstract |
Diploid5例の平均テロメア長は6.7kbpであり、G3を含む悪性度の高い例でテロメアが短かった。5例に共通してテロメアが有意に短縮する染色体は存在しないが、12p(Kras遺伝子搭載)は5例中3例で有意に短縮していた。染色体不安定性の指標であるアナフェーズブリッジの出現頻度はテロメア長と逆相関を示し、テロメアの短縮が染色体不安定性に深く関与していることが明らかになった。
|
-
-
[Journal Article] Luminal and cancer cells in the breast show more rapid telomere shortening than myoepithelial cells and fibroblasts.2008
Author(s)
Kurabayashi R, Takubo K, Aida J, Honma N, Poon SS, Kammori M, Izumiyama-Shimomura N, Nakamura KI, Tsuji EI, Matsuura M, Ogawa T, Kaminishi M.
-
Journal Title
Peer Reviewed
-
-
[Journal Article] Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epithelium.2008
Author(s)
Aida J, Izumiyama-Shimomura N, Nakamura K, Ishikawa N, Poon SS, Kammori M, Sawabe M, Arai T, Matsuura M, Fujiwara M, Kishimoto H, Takubo K.
-
Journal Title
Exp Gerontol. 43(9)
Pages: 833-9
-
-
[Journal Article] Telomeric DNA length in cerebral gray and white matter is associated with longevity in individuals aged 70 years or older.2007
Author(s)
Nakamura K, Takubo K, Izumiyama-Shimomura N, Sawabe M, Arai T, Kishimoto H, Fujiwara M, Kato M, Oshimura M, Ishii A, Ishikawa T. N.
-
Journal Title
Exp Gerontol. 42(10)
Pages: 944-50
Peer Reviewed
-
[Journal Article] Telomere length variations in 6 mucosal cell types of gastric tissue observed using a novel quantitative fluorescence in situ hybridization method.2007
Author(s)
Aida J, Izumiyama-Shimomura N, Nakamura K, Ishii A, Ishikawa N, Honma N, Kurabayashi R, Kammori M, Poon SS, Arai T, Takubo K.
-
Journal Title
Hum Pathol. 38(8)
Pages: 1192-200
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
