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2008 Fiscal Year Final Research Report

Analysis of the function of Oncostatain M in chronic hepatitis andliver fibrosis

Research Project

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Project/Area Number 19590383
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionThe University of Tokyo

Principal Investigator

TANAKA Minoru  The University of Tokyo, 分子細胞生物学研究所, 特任講師 (80321909)

Project Period (FY) 2007 – 2008
Keywords疾患モデル動物
Research Abstract

肝障害時におけるオンコスタチンM(OSM)の作用機序の解明を目指した。高脂肪食投与による肥満モデルでは、OSM 受容体KO マウスは野生型マウスに比べて有意に体重の増加を示し、肝臓内の脂質量が増加するなど、早期の脂肪肝を引き起こした。OSM はPPARg の発現を抑制することで脂肪肝を抑制していることが示唆された。また、肝炎惹起因子を投与したKO マウスは野生型マウスより感受性が高く、急性肝炎で死亡したことから、OSM には免疫抑制作用があることが示唆された。

  • Research Products

    (7 results)

All 2009 2008 2007

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (2 results)

  • [Journal Article] equallycontribution : corresponding author. Potentialhepatic stem cells reside in EpCAM+ cells ofnormal and injured mouse livers2009

    • Author(s)
      Okabe M, Tsukahara Y, Tanaka M, Suzuki K, Saito S, Kamiya Y, Tsujimura T,Nakamura K and Miyajima A.
    • Journal Title

      Development 136(11)

      Pages: 1951-60

    • Peer Reviewed
  • [Journal Article] equally contribution.p75 neurotrophin receptor is a marker forprecursors of stellate cells and portal fibroblastsin mouse fetal liver2008

    • Author(s)
      Suzuki K, Tanaka M, Watanabe N, Saito S,Nonaka H, Miyajima A
    • Journal Title

      Gastroenterology 135(1)

      Pages: 270-281

    • Peer Reviewed
  • [Journal Article] OncostatinM receptor-beta signaling limits monocytic cellrecruitment in acute inflammation2008

    • Author(s)
      Hams E et.al.
    • Journal Title

      J.Immunology 181(3)

      Pages: 2174-80

    • Peer Reviewed
  • [Journal Article] OncosatainM gene therapy attenuates liver damage inducedby dimethynitorsoamine in rats2007

    • Author(s)
      Hamada T.et.al.
    • Journal Title

      Am. J. Pathol. 171

      Pages: 872-881

    • Peer Reviewed
  • [Journal Article] Development of murine hepaticsinusoidal endothelial cells characterized by theexpression of hyaluronan receptors2007

    • Author(s)
      Nonaka H., Tanaka M., Suzuki K. and Miyajima A
    • Journal Title

      Dev. Dyn 236

      Pages: 2258-2267

    • Peer Reviewed
  • [Presentation] 肝幹細胞の分離と性状解析2008

    • Author(s)
      田中稔
    • Organizer
      肝細胞研究会
    • Place of Presentation
      静岡
    • Year and Date
      2008-06-28
  • [Presentation] 抗p75NTR 抗体を用いた胎生肝臓における間葉系前駆細胞の分離2007

    • Author(s)
      田中稔
    • Organizer
      同定BMB2007(日本分子生物学会・日本生化学会合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2007-12-12

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Published: 2010-06-10   Modified: 2016-04-21  

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