2008 Fiscal Year Final Research Report
Regulation of biological barrier and cell polarity formation
Project/Area Number |
19590398
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Experimental pathology
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Research Institution | Sapporo Medical University |
Principal Investigator |
CHIBA Hideki Sapporo Medical University, 医学部, 准教授 (00295346)
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Co-Investigator(Kenkyū-buntansha) |
SAWADA Norimasa 札幌医科大学, 医学部, 教授 (30154149)
INATOMI Syuichiro 札幌医科大学, 医学部, 研究員 (10437999)
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Project Period (FY) |
2007 – 2008
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Keywords | 病理学 / 細胞・組織 / 核内受容体 / 細胞極性 / 細胞間接着装置 |
Research Abstract |
ビタミンD受容体ノックアウト(VDRKO)マウスの腸組織とビタミンD_3依存性ヒト腸上皮細胞株を用いて、活性型ビタミンD_3がVDRを介して、腸上皮におけるタイト結合分子claudin-2及びclaudin-12の発現を誘導することを見出した。また、これらのclaudinsが腸上皮細胞間でカルシウムイオン(Ca^<2+>)の細胞間隙チャネルを形成し、Ca^<2+>の通過を制御することを突き止めた。本研究は、カルシウム代謝に新規の知見を加え、骨粗鬆症やカルシウム代謝異常に対する新たな予防・治療戦略になることが期待される。
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[Journal Article] Knockdown of tight junction protein claudin-2 prevents bile canalicular formation in WIF-B9 cells2009
Author(s)
Son S, Kojima T, Decaens C, Yamaguchi H, Ito T, Imamura M, Murata M, Tanaka S, Chiba H, Hirata K, Sawada N
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Journal Title
Histochem Cell Biol 131
Pages: 411-424
Peer Reviewed
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[Journal Article] Transforming growth factor-β induces epithelial to mesenchymal transition by down-regulation of claudin-1 expression and the fence function in adult rat hepatocytes2008
Author(s)
Kojima T, Takano K, Yamamoto T, Imamura M, Murata M, Son S, Yamaguchi H, Osanai M, Chiba H, Himi T, Sawada N
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Journal Title
Liver Int 28
Pages: 534-545
Peer Reviewed
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[Journal Article] Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro2008
Author(s)
Takano K, Kojima T, Ogasawara N, Go M, Kikuchi S, Ninomiya T, Kurose M, Koizumi J, Kamekura R, Murata M, Tanaka S, Chiba H, Himi T, Sawada N
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Journal Title
J Mol Histol 39
Pages: 265-273
Peer Reviewed
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[Journal Article] Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca^<2+> absorption between enterocytes2008
Author(s)
Fujita H, Sugimoto K, Inatomi S, Maeda T, Osanai M, Uchiyama Y, Yamamoto Y, Wada T, Kojima T, Yokozaki H, Yamashita T, Kato S, Sawada N, Chiba H
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Journal Title
Mol Biol Cell 19
Pages: 1912-1921
Peer Reviewed
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[Journal Article] Protein kinase C enhances tight junction barrier function of human nasal epithelial cells in primary culture by transcriptional regulation2008
Author(s)
Koizumi J, Kojima T, Ogasawara N, Kamekura R, Kurose M, Go M, Harimaya A, Murata M, Osanai M, Chiba H, Himi T, Sawada N
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Journal Title
Mol Pharmacol 74
Pages: 432-442
Peer Reviewed
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[Journal Article] IGF-I regulates tight-junction protein claudin-1 during differentiation of osteoblast-like MC3T3-E1 cells via a MAP-kinase pathway2008
Author(s)
Hatakeyama N, Kojima T, Iba K, Murata M, Thi MM, Spray DC, Osanai M, Chiba H, Ishii S, Yamashita T, Sawada N
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Journal Title
Cell Tissue Res 334
Pages: 243-254
Peer Reviewed
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[Journal Article] Induction of claudins in passaged hTERT-transfected human nasal epithelial cells with an extended life span2007
Author(s)
Kurose M, Kojima T, Koizumi J, Kamekura R, Ninomiya T, Murata M, Ichimiya S, Osanai M, Chiba H, Himi T, Sawada N
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Journal Title
Cell Tissue Res 330
Pages: 63-74
Peer Reviewed
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[Journal Article] Tight junction proteins and signal transduction pathways in hepatocytes
Author(s)
Kojima T, Murata M, Yamamoto T, Lan M, Imamura M, Son S, Takano K-i, Yamaguchi H, Ito T, Tanaka S, Chiba H, Hirata K, Sawada N
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Journal Title
Histol Histopathol (in press)
Peer Reviewed
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