2009 Fiscal Year Final Research Report
Analysis of development and cancer in microRNA transgenic mice
| Project/Area Number |
19590408
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Chubu University |
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Principal Investigator |
IWAMOTO Takashi Chubu University, 生命健康科学部, 教授 (60223426)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Masashi 中部大学, 生命健康科学部, 教授 (10281073)
ICHIHARA Masatoshi 中部大学, 生命健康科学部, 教授 (00314013)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 疾患動物モデル / マイクロRNA / 大腸癌 |
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| Research Abstract |
In the present study, we analyze the effect of microRNAs, recently discovered small non-coding RNAs, on the development and pathogenesis of cancer using their transgenic mice. We show that the tumor development of the small intestines of APC^<min> mice, which are model mice of familial adenomatous polyposis, is inhibited when crossed to miR-143 transgenic mice. We also demonstrate that proto-oncogene c-myc is downregulated in transgenic tumors.
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