2010 Fiscal Year Final Research Report
Analysis of the molecular mechanism in gastrointestinal pacemaker cell using KIT knock-in animal
| Project/Area Number |
19590411
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
ISOZAKI Koji Hyogo College of Medicine, 医学部, 非常勤講師 (00425117)
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| Co-Investigator(Kenkyū-buntansha) |
HIROTA Seiichi 兵庫医科大学, 医学部, 教授 (50218856)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 多発性GIST / ノックインマウス / カハールの介在細胞 / c-kit遺伝子 / 生殖系列 / 機能獲得性突然変異 |
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| Research Abstract |
CADM1 is an adhesion molecule mediating nerve-mast cell interactions. It was demonstrated that both CADM1 protein and mRNA expressed in GISTs of human small intestine but not in GISTs of human stomach. These results suggested that types of ICCs which are considered to be an origin of GISTs are different between gastric and intestinal GISTs.
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