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2008 Fiscal Year Final Research Report

Analysis of antitumor effect by antiangiogenic activity of interleukin-27

Research Project

  • PDF
Project/Area Number 19590418
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionTokyo Metropolitan Organization for Medical Research

Principal Investigator

SHIMIZU Motomu  Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 主任研究員 (10124463)

Co-Investigator(Kenkyū-buntansha) SHIMAMURA Mariko  財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 主任研究員 (00124462)
YOSHIMOTO Takayuki  東京医科大学, 医学部, 助教授 (80202406)
Project Period (FY) 2007 – 2008
Keywords癌 / 免疫学 / 抗腫瘍作用 / インターロイキン27 / IL-27 / 血管新生阻害
Research Abstract

本研究ではIL-6/IL-12ファミリーメンバーのIL-27による抗腫瘍作用機構について検討した。高転移性で低抗原性の悪性メラノーマB16F10にIL-27cDNAを導入した腫瘍において、IL-27は強い抗腫瘍効果を示した。IL-27の血管新生阻害を検討すると、強い阻害作用を示した。従って、IL-27の抗腫瘍作用は免疫増強ばかりではなく、血管新生阻害が重要であること示唆された。IL-27はIL-12に比べ毒性は少なく、抗腫瘍効果が同等であることから、がんの免疫療法に有望であることが期待される。

  • Research Products

    (19 results)

All 2008 2007 Other

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (13 results) Remarks (1 results)

  • [Journal Article] Anti-proliferative activity of IL-27 on melanoma.2008

    • Author(s)
      T. Yoshimoto, N. Morishima, I. Mizoguchi, M. Shimizu, H. Nagai, S. Oniki, M. Oka, C. Nishigori, J. Mizuguchi
    • Journal Title

      J. Immunol. 180

      Pages: 6527-6535

    • Peer Reviewed
  • [Journal Article] SAR oriented novel discovery of substituted phenylpropanoic acid-PPAR pan agonist with 4-adamantylphenyl group as a hydrophobic tail part.2008

    • Author(s)
      J. Kasuga, D. Yamasaki, K. Ogura, M. Shimizu, M. Sato, M. Makishima, T. Doi, Y. Hashimoto, H. Miyachi
    • Journal Title

      Bioorg. Med. Chem. Lett. 18

      Pages: 1110-1115

    • Peer Reviewed
  • [Journal Article] Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.2007

    • Author(s)
      S. Lee, C. Shinji, K. Ogura, M. Shimizu, S. Maeda, M. Sato, M. Yoshida, Y. Hashimoto, H. Miyachi
    • Journal Title

      Bioorg. Med. Chem. Lett. 17

      Pages: 4895-4900

    • Peer Reviewed
  • [Journal Article] 正電荷ポリマーによる乳癌細胞に対する遺伝子導入の基礎研究. 査読有2007

    • Author(s)
      武田泰隆、榮光子、善本隆之、森本純司、清水本武、柳衛広宣
    • Journal Title

      乳癌基礎研究 16

      Pages: 43-49

    • Peer Reviewed
  • [Journal Article] IL-27の血管新生抑制作用2007

    • Author(s)
      清水本武, 島村眞里子, 善本隆之
    • Journal Title

      臨床免疫 47

      Pages: 298-302

  • [Presentation] Analysis of in vivo antitumor activity of IL-27 against melanoma.2008

    • Author(s)
      Shimizu, M., Mizuguchi, J, Yoshimoto, T.
    • Organizer
      The 38^<th> Annual Meeting of the Japanese society for immunology.
    • Place of Presentation
      Kyoto
    • Year and Date
      20081201-03
  • [Presentation] Analysis of antitumor activity of IL-2.2008

    • Author(s)
      Shimizu, M., Sato, M., Ogura, K., Nishito, Y., Takeda, Y., Mizuguchi, J, Yoshimoto, T.
    • Organizer
      The 67^<th> Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Nagoya
    • Year and Date
      20081028-30
  • [Presentation] Comprehensive gene expression analysis of melanoma B16 cells that Hgs expression level changed metastasis activity.2008

    • Author(s)
      Ogura, K., Kawashima, I., Ishikawa, Y-I., Sato, M., Shimizu, M.
    • Organizer
      The 67^<th> Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Nagoya
    • Year and Date
      20081028-30
  • [Presentation] A novel PPAR alpha/beta/gamma-pan agonist inhibits cell growth in human pancreatic cancer cell lines.2008

    • Author(s)
      Sato, M., Yajima Y., Ogura, K., Shimizu, M., Nishitho, Y., Miyachi H.
    • Organizer
      67th Annual Meeting of the Japanese cancer association.
    • Place of Presentation
      Nagoya
    • Year and Date
      20081028-30
  • [Presentation] 正電荷ポリマーを用いたFasリガンド(FasL)遺伝子導入による乳癌遺伝子治療に向けた基礎的研究2008

    • Author(s)
      武田泰隆, 榮 光子, 善本隆之, 森本純司, 清水本武, 柳衛宏宣, 螺良愛朗
    • Organizer
      第18回乳癌基礎研究会
    • Place of Presentation
      福島
    • Year and Date
      20080712-13
  • [Presentation] TIPP-703, A peroxisome proliferator-activated receptor pan agonist, induces a G1-phase arrest in human pancreatic carcinoma cell lines.2008

    • Author(s)
      Sato, M., Yajima Y., Ogura, K., Shimizu, M., Miyachi H.
    • Organizer
      The 33rd FEBS Congress - 11th IUBMB Conference "Biochemistry of Cell Regulation"
    • Place of Presentation
      Athens (Greece)
    • Year and Date
      20080628-0703
  • [Presentation] Effects of Hgs on metastasis ability of mouse melanoma B16 cells.2008

    • Author(s)
      Ogura, K., Kawashima, I., Sato, M., Shimizu, M.
    • Organizer
      The 33rd FEBS Congress & 11th IUBMB Conference
    • Place of Presentation
      Athens (Greece)
    • Year and Date
      20080627-0703
  • [Presentation] Hgs高発現および抑制マウスメラノーマB16細胞の遺伝子発現プロファイリング2007

    • Author(s)
      小倉潔, 佐藤眞友美, 清水本武
    • Organizer
      第30回日本分子生物学会年会・第80回生化学会大会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      20071211-15
  • [Presentation] Role of chemokines in antitumor activity of Fas ligand (CD95L)-expressing tumor.2007

    • Author(s)
      Shimizu, M., Mizuguchi, J., Yoshimoto, T.
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      20071120-22
  • [Presentation] Role of macrophages and neutrophils in antitumor activity of Fas ligand (CD95L)-expressing tumor.2007

    • Author(s)
      Shimizu, M., Sato, M., Ogura, K., Takeda, Y., Mizuguchi, J, Yoshimoto, T.
    • Organizer
      The 66^<th> Annual Meeting of the Japanese Cancer Association.
    • Place of Presentation
      Yokohama
    • Year and Date
      20071003-05
  • [Presentation] Effects of RNA Interference of GEF-1/Hgs on Metastasis of Mouse Melanoma B16 cells.2007

    • Author(s)
      Ogura, K., Horiguchi, S., Sato, M., Shimizu, M.
    • Organizer
      The 66^<th> Annual Meeting of the Japanese Cancer Association.
    • Place of Presentation
      Yokohama
    • Year and Date
      20071003-05
  • [Presentation] Novel PPAR α, γ dual agonists induce a G1-phase arrest in pancreatic cancer cells.2007

    • Author(s)
      Sato, M., Ogura, K., Shimizu, M., Kunimasa, K., Ohta, T., Kaji, K., Miyachi, H.
    • Organizer
      The 66^<th> Annual Meeting of the Japanese Cancer Association.
    • Place of Presentation
      Yokohama
    • Year and Date
      20071003-05
  • [Presentation] L-carnosine, an endogenous bioactive dipeptide inhibits angiogenesis and tumor metastasis.2007

    • Author(s)
      Shimamura, M., Ashino, H., Shimizu, M., Yamamoto, Y., Minamikawa-Tachino, R., Takahashi, S.
    • Organizer
      The 66^<th> Annual Meeting of the Japanese Cancer Association.
    • Place of Presentation
      Yokohama
    • Year and Date
      20071003-05
  • [Remarks]

    • URL

      http://www.rinshoken.or.jp/

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Published: 2010-06-10   Modified: 2016-04-21  

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