2009 Fiscal Year Final Research Report
Characterization of dermal allergic murine models induce by repeated application of non protein substance from pathogenic fungi.
| Project/Area Number |
19590459
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
ADACHI Yoshiyuki Tokyo University of Pharmacy and Life Science, 薬学部, 准教授 (60222634)
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| Co-Investigator(Renkei-kenkyūsha) |
OHNO Naohito 東京薬科大学, 薬学部, 教授 (80152213)
MIURA Noriko 東京薬科大学, 薬学部, 講師 (30218036)
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| Project Period (FY) |
2007 – 2009
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| Keywords | カンジダ / β-グルカン / アトピー性皮膚炎 / Th2 / dectin-1 / CR3 |
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| Research Abstract |
The effect of fungal beta-glucan (BG) on the allergic dermatitis, animal model using tape-stripping and BG-painting model on mice were examined. Repeated application of Candida-derived BG and antigen accelerated the inflammation in skin tissue. Characterization of BG receptors concerning the BG-induced inflammation suggested that complement receptors support BG-recognition and the immune cell activation induced by dectin-1-mediated cell activity.
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